FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PIGP



General Information
Gene Symbol:   
PIGP
Protein name:   
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
2.4.1.198
Organs:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

• GPI-GnT: GlcNAcT activity that is necessary to form the core glycan structure on GPI-anchored proteins
• Subunit PIGA has catalytic activity, while PIGC, PIGH, PIGQ, PIGP and PIGY have other essential functions
• DPM2 is regulatory and it functions to enhance GPI-GnT activity

Related Pathway
KEGG ORTHOLOGY:   
K03861
KEGG Pathway:   
ko00563  ko01100 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
P57054 
NCBI GeneID:   
51227
GlyMap GeneID:   
51227
DNA aRefSeq:   
NM_001320480.1 
Protein RefSeq:   
NP_001307409.1 
BRENDA:   
Kinetic info.
OMIM number:   
605938
GeneCards database:   
PIGP
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     No reaction
Product:  
     
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-5197-5p 50-57 -0.856 99.0 -0.856 99.0 noncon
hsa-miR-6716-5p 199-206 -0.801 99.0 -0.704 99.0 noncon
hsa-miR-4694-5p 18-25 -0.789 99.0 -0.789 99.0 noncon
hsa-miR-3682-5p 102-109 -0.612 99.0 -0.6 99.0 noncon
hsa-miR-338-5p 149-156 -0.535 99.0 -0.477 99.0 noncon
hsa-miR-664a-3p 174-181 -0.525 99.0 -0.467 99.0 noncon
hsa-miR-1304-5p 2302-2309 -0.514 99.0 -0.001 32.0 noncon
hsa-miR-296-5p 322-329 -0.487 97.0 -0.002 21.0 noncon
hsa-miR-3152-5p 5925-5932 -0.486 99.0 -0.001 31.0 noncon
hsa-miR-493-3p 122-128 -0.483 99.0 -0.461 99.0 noncon
hsa-miR-4278 3990-3997 -0.483 97.0 -0.001 15.0 noncon
hsa-miR-4725-5p 6075-6082 -0.454 98.0 -0.001 19.0 noncon
hsa-miR-664a-3p 144-151 -0.445 99.0 -0.398 99.0 noncon
hsa-miR-153-3p 550-557 -0.437 98.0 -0.002 32.0 noncon
hsa-miR-1909-3p 6271-6278 -0.436 98.0 -0.001 28.0 noncon
hsa-miR-6770-5p 124-130 -0.433 99.0 -0.414 99.0 noncon
hsa-miR-7153-3p 4512-4519 -0.432 99.0 -0.001 47.0 noncon
hsa-miR-4674 3821-3828 -0.43 99.0 -0.001 39.0 noncon
hsa-miR-6749-3p 4462-4469 -0.43 98.0 -0.001 31.0 noncon
hsa-miR-6810-3p 4857-4864 -0.424 98.0 -0.001 34.0 noncon
hsa-miR-133a-3p.1 4759-4766 -0.423 97.0 -0.001 24.0 noncon
hsa-miR-4437 3820-3827 -0.423 98.0 -0.001 15.0 noncon
hsa-miR-1972 909-916 -0.422 99.0 -0.002 21.0 noncon
hsa-miR-3188 2300-2307 -0.42 99.0 -0.001 35.0 noncon
hsa-miR-1224-3p 681-688 -0.418 99.0 -0.002 37.0 noncon
hsa-miR-6082 29-35 -0.415 97.0 -0.415 98.0 noncon
hsa-miR-3152-5p 666-673 -0.411 98.0 -0.002 33.0 noncon
hsa-miR-4283 2481-2488 -0.411 97.0 -0.001 26.0 noncon
hsa-miR-6801-3p 4857-4864 -0.41 97.0 -0.001 31.0 noncon
hsa-miR-6722-3p 6271-6278 -0.399 98.0 -0.001 25.0 noncon
hsa-miR-4450 6145-6152 -0.398 97.0 -0.001 16.0 noncon
hsa-miR-6766-5p 6119-6126 -0.394 97.0 -0.001 23.0 noncon
hsa-miR-6756-5p 6119-6126 -0.391 96.0 -0.001 19.0 noncon
hsa-miR-636 24-30 -0.387 98.0 -0.387 99.0 noncon
hsa-miR-4711-5p 1842-1849 -0.382 98.0 -0.001 22.0 noncon
hsa-miR-6736-5p 2630-2637 -0.381 98.0 -0.001 23.0 noncon
hsa-miR-888-3p 234-241 -0.38 99.0 -0.002 30.0 noncon
hsa-miR-1273f 83-89 -0.377 99.0 -0.37 99.0 noncon
hsa-miR-6827-5p 5941-5948 -0.367 95.0 -0.001 21.0 noncon
hsa-miR-3974 121-127 -0.365 98.0 -0.349 98.0 noncon
hsa-miR-6800-5p 3946-3953 -0.364 98.0 -0.001 18.0 noncon
hsa-miR-1260a 682-689 -0.362 97.0 -0.002 31.0 noncon
hsa-miR-1260b 682-689 -0.362 97.0 -0.002 31.0 noncon
hsa-miR-4701-3p 2630-2637 -0.362 98.0 -0.001 21.0 noncon
hsa-miR-6734-3p 685-692 -0.361 97.0 -0.002 41.0 noncon
hsa-miR-23b-5p 4244-4251 -0.359 96.0 -0.001 28.0 noncon
hsa-miR-26a-1-3p 177-183 -0.358 98.0 -0.321 98.0 noncon
hsa-miR-26a-2-3p 177-183 -0.358 98.0 -0.321 98.0 noncon
hsa-miR-6789-3p 5705-5711 -0.356 92.0 -0.001 13.0 noncon
hsa-miR-4711-3p 393-400 -0.355 97.0 -0.002 28.0 noncon
hsa-miR-4716-3p 3989-3996 -0.355 95.0 -0.001 10.0 noncon
hsa-miR-1262 2630-2637 -0.354 98.0 -0.001 21.0 noncon
hsa-miR-3613-5p 5999-6006 -0.352 97.0 -0.001 28.0 noncon
hsa-miR-5193 965-972 -0.351 96.0 -0.002 40.0 noncon
hsa-miR-6794-5p 3989-3996 -0.35 95.0 -0.001 11.0 noncon
hsa-miR-3173-5p 2110-2117 -0.35 97.0 -0.001 34.0 noncon
hsa-miR-6799-3p 2110-2117 -0.35 97.0 -0.001 32.0 noncon
hsa-miR-6871-5p 202-208 -0.349 98.0 -0.312 98.0 noncon
hsa-miR-4715-3p 1666-1673 -0.344 98.0 -0.001 44.0 noncon
hsa-miR-892b 4277-4284 -0.342 96.0 -0.001 18.0 noncon
hsa-miR-4256 4730-4737 -0.342 96.0 -0.001 29.0 noncon
hsa-miR-1291 4617-4624 -0.334 95.0 -0.001 19.0 noncon
hsa-miR-6798-5p 2948-2955 -0.331 97.0 -0.001 26.0 noncon
hsa-miR-216b-3p 844-851 -0.331 98.0 -0.002 36.0 noncon
hsa-miR-2355-3p 2669-2676 -0.33 95.0 -0.001 22.0 noncon
hsa-miR-6774-5p 3932-3938 -0.329 97.0 -0.001 37.0 noncon
hsa-miR-6775-3p 4617-4624 -0.328 94.0 -0.001 17.0 noncon
hsa-miR-942-5p 100-106 -0.327 98.0 -0.321 98.0 noncon
hsa-miR-6880-5p 1457-1464 -0.325 95.0 -0.001 22.0 noncon
hsa-miR-6752-3p 1938-1944 -0.324 95.0 -0.001 31.0 noncon
hsa-miR-6883-3p 5854-5861 -0.32 97.0 -0.001 26.0 noncon
hsa-miR-6783-5p 5978-5985 -0.32 97.0 -0.001 15.0 noncon
hsa-miR-7974 1514-1521 -0.318 94.0 -0.001 20.0 noncon
hsa-miR-5196-3p 448-455 -0.316 97.0 -0.001 43.0 noncon
hsa-miR-3159 4538-4545 -0.315 98.0 -0.001 23.0 noncon
hsa-miR-3179 6324-6331 -0.314 96.0 -0.001 28.0 noncon
hsa-miR-4317 290-297 -0.313 95.0 -0.001 36.0 noncon
hsa-miR-3620-3p 500-507 -0.311 98.0 -0.001 32.0 noncon
hsa-miR-6776-3p 1774-1781 -0.308 97.0 -0.001 39.0 noncon
hsa-miR-3127-3p 978-985 -0.305 94.0 -0.001 32.0 noncon
hsa-miR-26a-2-3p 953-960 -0.305 97.0 -0.001 30.0 noncon
hsa-miR-766-5p 253-260 -0.305 96.0 -0.001 19.0 noncon
hsa-miR-26a-1-3p 953-960 -0.305 97.0 -0.001 30.0 noncon
hsa-miR-656-5p 5164-5170 -0.305 93.0 -0.001 17.0 noncon
hsa-miR-3927-3p 1545-1552 -0.304 96.0 -0.001 18.0 noncon
hsa-miR-5000-3p 314-321 -0.303 97.0 -0.001 21.0 noncon
hsa-miR-2467-5p 4989-4996 -0.301 97.0 -0.001 47.0 noncon
hsa-miR-8052 4183-4190 -0.3 95.0 -0.001 22.0 noncon
hsa-miR-4505 6366-6373 -0.299 95.0 -0.001 23.0 noncon
hsa-miR-4746-3p 3649-3655 -0.299 92.0 -0.001 12.0 noncon
hsa-miR-3121-5p 584-590 -0.298 97.0 -0.001 43.0 noncon
hsa-miR-6756-3p 978-985 -0.297 94.0 -0.001 31.0 noncon
hsa-miR-3199 4183-4190 -0.297 94.0 -0.001 20.0 noncon
hsa-miR-635 3932-3938 -0.296 96.0 -0.001 38.0 noncon
hsa-miR-5006-5p 5269-5276 -0.296 95.0 -0.001 25.0 noncon
hsa-miR-6791-5p 3915-3922 -0.295 95.0 -0.001 26.0 noncon
hsa-miR-555 999-1006 -0.294 93.0 -0.001 18.0 noncon
hsa-miR-7151-5p 1017-1024 -0.293 98.0 -0.001 49.0 noncon
hsa-miR-6719-3p 233-239 -0.292 97.0 -0.001 34.0 noncon
hsa-miR-5187-3p 959-966 -0.291 98.0 -0.001 47.0 noncon
hsa-miR-4260 3140-3147 -0.291 94.0 -0.001 28.0 noncon
hsa-miR-4255 1506-1513 -0.29 98.0 -0.001 45.0 noncon
hsa-miR-142-3p.1 1508-1515 -0.29 91.0 -0.001 18.0 noncon
hsa-miR-4260 2483-2490 -0.29 94.0 -0.001 28.0 noncon
hsa-miR-4761-3p 1751-1758 -0.288 98.0 -0.001 34.0 noncon
hsa-miR-6810-3p 1939-1945 -0.288 93.0 -0.001 33.0 noncon
hsa-miR-5580-5p 2142-2149 -0.287 93.0 -0.001 17.0 noncon
hsa-miR-4292 3915-3922 -0.287 95.0 -0.001 27.0 noncon
hsa-miR-656-5p 1400-1406 -0.287 91.0 -0.001 17.0 noncon
hsa-miR-6778-3p 5595-5601 -0.285 95.0 -0.001 32.0 noncon
hsa-miR-6808-5p 4888-4895 -0.282 98.0 -0.001 40.0 noncon
hsa-miR-516b-5p 1898-1905 -0.281 95.0 -0.001 25.0 noncon
hsa-miR-5095 1137-1144 -0.28 95.0 -0.001 35.0 noncon
hsa-miR-6873-3p 752-759 -0.279 95.0 -0.001 29.0 noncon
hsa-miR-939-5p 3987-3993 -0.278 94.0 -0.001 26.0 noncon
hsa-miR-6801-3p 1939-1945 -0.278 93.0 -0.001 30.0 noncon
hsa-miR-1343-5p 3987-3993 -0.278 94.0 -0.001 29.0 noncon
hsa-miR-155-3p 820-827 -0.278 92.0 -0.001 18.0 noncon
hsa-miR-4316 4991-4998 -0.278 96.0 -0.001 38.0 noncon
hsa-miR-4482-3p 178-184 -0.277 98.0 -0.249 98.0 noncon
hsa-miR-584-5p 66-72 -0.276 95.0 -0.276 96.0 noncon
hsa-miR-1289 2069-2075 -0.275 92.0 -0.001 25.0 noncon
hsa-miR-6831-5p 1545-1552 -0.275 94.0 -0.001 17.0 noncon
hsa-miR-23a-5p 4244-4251 -0.275 95.0 -0.001 36.0 noncon
hsa-miR-1289 2033-2039 -0.274 92.0 -0.001 25.0 noncon
hsa-miR-6893-5p 4888-4895 -0.274 97.0 -0.001 41.0 noncon
hsa-miR-8076 3878-3885 -0.273 96.0 -0.001 19.0 noncon
hsa-miR-6773-5p 323-329 -0.272 92.0 -0.001 28.0 noncon
hsa-miR-9500 5360-5367 -0.271 97.0 -0.001 34.0 noncon
hsa-miR-200c-5p 6306-6313 -0.271 95.0 -0.001 29.0 noncon
hsa-miR-1289 2015-2021 -0.27 92.0 -0.001 25.0 noncon
hsa-miR-3529-5p 5292-5298 -0.27 94.0 -0.001 23.0 noncon
hsa-miR-4451 1544-1550 -0.27 90.0 -0.001 17.0 noncon
hsa-miR-6884-5p 2301-2307 -0.27 95.0 -0.001 22.0 noncon
hsa-miR-744-3p 5812-5819 -0.268 94.0 -0.001 32.0 noncon
hsa-miR-3152-5p 506-512 -0.267 94.0 -0.001 31.0 noncon
hsa-miR-323b-3p 6060-6067 -0.266 97.0 -0.001 40.0 noncon
hsa-miR-663b 4619-4626 -0.265 95.0 -0.001 33.0 noncon
hsa-miR-1304-3p 2729-2736 -0.264 98.0 -0.001 35.0 noncon
hsa-miR-6886-3p 801-807 -0.263 91.0 -0.001 28.0 noncon
hsa-miR-1236-5p 4407-4414 -0.262 94.0 -0.001 34.0 noncon
hsa-miR-4421 3534-3541 -0.261 94.0 -0.001 25.0 noncon
hsa-miR-3691-5p 3169-3176 -0.26 91.0 -0.001 25.0 noncon
hsa-miR-615-5p 2454-2460 -0.258 91.0 -0.001 23.0 noncon
hsa-miR-4438 5053-5059 -0.258 97.0 -0.001 29.0 noncon
hsa-miR-485-5p 2301-2307 -0.258 94.0 -0.001 22.0 noncon
hsa-miR-6721-5p 4006-4012 -0.257 91.0 -0.001 24.0 noncon
hsa-miR-6511b-5p 3458-3464 -0.256 94.0 -0.001 36.0 noncon
hsa-miR-4507 4114-4121 -0.256 94.0 -0.001 33.0 noncon
hsa-miR-4727-5p 5869-5876 -0.255 94.0 -0.001 20.0 noncon
hsa-miR-6750-5p 1044-1051 -0.255 97.0 -0.001 46.0 noncon
hsa-miR-3117-5p 3857-3863 -0.254 95.0 -0.001 15.0 noncon
hsa-miR-885-5p 457-463 -0.254 96.0 -0.001 40.0 noncon
hsa-miR-518c-5p 257-264 -0.253 96.0 -0.001 26.0 noncon
hsa-miR-651-5p 4540-4547 -0.252 96.0 -0.001 30.0 noncon
hsa-miR-4470 48-54 -0.251 96.0 -0.251 97.0 noncon
hsa-miR-4436a 314-321 -0.251 97.0 -0.001 30.0 noncon
hsa-miR-5582-3p 43-49 -0.25 99.0 -0.25 99.0 noncon
hsa-miR-6078 1254-1260 -0.25 92.0 -0.001 12.0 noncon
hsa-miR-6878-5p 4133-4139 -0.25 93.0 -0.001 15.0 noncon
hsa-miR-6784-3p 502-508 -0.25 92.0 -0.001 36.0 noncon