FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGT1A8



General Information
Gene Symbol:   
UGT1A8
Protein name:   
UDP-glucuronosyltransferase 1A8
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.17
Tissues:   
Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   
+ R →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• UGTs are glucuronyltransferases involved in the glucuronidation pathway. This involves the addition of glucuronic acid to excretables such as bilirubin, xenobiotics, and drugs. Substrates tend to be lipophilic in nature.
• Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-156588
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9HAW9 
NCBI GeneID:   
54576
GlyMap GeneID:   
54576
DNA aRefSeq:   
NM_019076.4 
Protein RefSeq:   
NP_061949.3 
BRENDA:   
Kinetic info.
OMIM number:   
191740
GeneCards database:   
UGT1A8
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     R
Product:  
     GlcA(??-?)R
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 240 220 200 180 160 140 120 100 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000373450 ELF1
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-185-3p 121-128 -0.704 99.0 -0.704 99.0 noncon
hsa-miR-8065 699-706 -0.531 99.0 -0.531 99.0 noncon
hsa-miR-6736-3p 629-636 -0.52 99.0 -0.52 99.0 noncon
hsa-miR-6839-3p 646-653 -0.471 98.0 -0.471 99.0 noncon
hsa-miR-491-3p 108-115 -0.454 98.0 -0.454 99.0 noncon
hsa-miR-3194-5p 263-270 -0.428 98.0 -0.428 99.0 noncon
hsa-miR-200a-3p 69-76 -0.426 99.0 -0.426 99.0 con
hsa-miR-141-3p 69-76 -0.426 99.0 -0.426 99.0 con
hsa-miR-3121-3p 738-745 -0.391 99.0 -0.001 39.0 noncon
hsa-miR-5093 45-52 -0.356 99.0 -0.356 99.0 noncon
hsa-miR-5088-3p 471-478 -0.356 98.0 -0.356 98.0 noncon
hsa-miR-6835-3p 131-138 -0.351 99.0 -0.351 99.0 noncon
hsa-miR-6743-5p 342-349 -0.336 97.0 -0.336 98.0 noncon
hsa-miR-4688 342-349 -0.334 96.0 -0.334 97.0 noncon
hsa-miR-3158-5p 384-391 -0.317 98.0 -0.317 98.0 noncon
hsa-miR-218-2-3p 30-36 -0.317 97.0 -0.317 98.0 noncon
hsa-miR-4793-5p 224-231 -0.314 98.0 -0.314 98.0 noncon
hsa-miR-4496 697-704 -0.312 99.0 -0.312 99.0 noncon
hsa-miR-4656 120-126 -0.302 97.0 -0.302 97.0 noncon
hsa-miR-4509 488-495 -0.298 98.0 -0.298 98.0 noncon
hsa-miR-135b-3p 701-707 -0.295 91.0 -0.295 93.0 noncon
hsa-miR-4999-5p 655-661 -0.292 94.0 -0.292 96.0 noncon
hsa-miR-6716-5p 34-40 -0.291 94.0 -0.291 96.0 noncon
hsa-miR-152-3p 526-533 -0.287 93.0 -0.287 95.0 noncon
hsa-miR-148b-3p 526-533 -0.287 93.0 -0.287 95.0 noncon
hsa-miR-148a-3p 526-533 -0.287 93.0 -0.287 95.0 noncon
hsa-miR-183-5p.1 235-241 -0.286 95.0 -0.286 96.0 noncon
hsa-miR-3123 143-149 -0.271 99.0 -0.271 99.0 noncon
hsa-miR-4489 122-128 -0.269 95.0 -0.269 96.0 noncon
hsa-miR-1972 300-306 -0.266 95.0 -0.266 97.0 noncon
hsa-miR-3972 264-270 -0.263 94.0 -0.263 96.0 noncon
hsa-miR-6865-5p 453-459 -0.255 93.0 -0.255 95.0 noncon
hsa-miR-6815-5p 453-459 -0.255 93.0 -0.255 95.0 noncon