FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGT2B17



General Information
Gene Symbol:   
UGT2B17
Protein name:   
UDP-glucuronosyltransferase 2B17
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.17
Organs:   
Reaction (SNFG):   
+ R →
+ null
Reaction (IUBMB):   
No specified reaction.
About

• UGTs are glucuronyltransferases involved in the glucuronidation pathway. This involves the addition of glucuronic acid to excretables such as bilirubin, xenobiotics, and drugs. Substrates tend to be lipophilic in nature.
• Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-156588
Related Database
Organism:   
Homo sapiens
Uniprot:   
O75795 
NCBI GeneID:   
7367
GlyMap GeneID:   
7367
DNA aRefSeq:   
NM_001077.3 
Protein RefSeq:   
NP_001068.1 
BRENDA:   
Kinetic info.
OMIM number:   
601903
GeneCards database:   
UGT2B17
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     R
Product:  
     GlcA(??-?)R
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 240 220 200 180 160 140 120 100 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 4 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000317746
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6881-5p 264-271 -0.713 99.0 -0.713 99.0 noncon
hsa-miR-6742-5p 266-273 -0.628 99.0 -0.628 99.0 noncon
hsa-miR-4786-3p 380-387 -0.581 99.0 -0.581 99.0 noncon
hsa-miR-6828-3p 392-399 -0.538 99.0 -0.538 99.0 noncon
hsa-miR-767-3p 391-398 -0.52 99.0 -0.52 99.0 noncon
hsa-miR-124-5p 314-321 -0.511 99.0 -0.511 99.0 noncon
hsa-miR-4699-5p 425-432 -0.497 99.0 -0.497 99.0 noncon
hsa-miR-496.1 364-371 -0.432 98.0 -0.432 99.0 noncon
hsa-miR-5004-3p 254-261 -0.426 98.0 -0.426 99.0 noncon
hsa-miR-656-3p 211-218 -0.421 99.0 -0.421 99.0 noncon
hsa-miR-147a 269-276 -0.413 99.0 -0.413 99.0 noncon
hsa-miR-7843-3p 381-387 -0.406 98.0 -0.406 98.0 noncon
hsa-miR-548av-5p 159-166 -0.405 99.0 -0.405 99.0 noncon
hsa-miR-548k 159-166 -0.405 99.0 -0.405 99.0 noncon
hsa-miR-569 325-332 -0.399 99.0 -0.399 99.0 noncon
hsa-miR-802 279-286 -0.379 99.0 -0.379 99.0 noncon
hsa-miR-6796-5p 267-273 -0.369 96.0 -0.369 97.0 noncon
hsa-miR-555 116-122 -0.356 96.0 -0.356 97.0 noncon
hsa-miR-4436b-5p 17-24 -0.346 98.0 -0.346 99.0 noncon
hsa-miR-1289 38-44 -0.335 95.0 -0.335 96.0 noncon
hsa-miR-5010-3p 317-324 -0.333 98.0 -0.333 99.0 noncon
hsa-miR-182-5p 415-421 -0.333 96.0 -0.333 97.0 noncon
hsa-miR-376a-3p 199-205 -0.33 97.0 -0.33 98.0 noncon
hsa-miR-6854-5p 283-289 -0.33 98.0 -0.33 98.0 noncon
hsa-miR-376b-3p 199-205 -0.33 97.0 -0.33 98.0 noncon
hsa-miR-4758-5p 336-342 -0.324 98.0 -0.324 98.0 noncon
hsa-miR-6792-3p 74-80 -0.319 97.0 -0.319 97.0 noncon
hsa-miR-491-5p 267-273 -0.318 96.0 -0.318 97.0 noncon
hsa-miR-1238-5p 336-342 -0.313 98.0 -0.313 98.0 noncon
hsa-miR-8054 159-166 -0.311 99.0 -0.311 99.0 noncon
hsa-miR-944 432-439 -0.308 99.0 -0.308 99.0 noncon
hsa-miR-376c-3p 178-184 -0.305 97.0 -0.305 97.0 noncon
hsa-miR-6806-3p 285-291 -0.303 97.0 -0.303 97.0 noncon
hsa-miR-3928-5p 285-291 -0.303 97.0 -0.303 98.0 noncon
hsa-miR-6818-5p 300-306 -0.295 98.0 -0.295 99.0 noncon
hsa-miR-382-5p 112-119 -0.292 99.0 -0.292 99.0 noncon
hsa-miR-548as-3p 64-71 -0.284 98.0 -0.284 99.0 noncon
hsa-miR-5579-3p 195-201 -0.271 96.0 -0.271 98.0 noncon
hsa-miR-494-3p 295-302 -0.268 98.0 -0.268 99.0 noncon