FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35A1



General Information
Gene Symbol:   
SLC35A1
Protein name:   
CMP-sialic acid transporter
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

CMP-Neu5Ac [cyto] or CMP-Sia [cyto] → CMP-Neu5Ac [Golgi] or CMP-Sia [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• This is an antiport of CMP and transports CMP-sialic acid from the cytosol into the lumen of the medial and trans cisternae of the Golgi apparatus

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-4085001
Related Database
Organism:   
Homo sapiens
Uniprot:   
P78382 
NCBI GeneID:   
10559
GlyMap GeneID:   
10559
DNA aRefSeq:   
NM_001168398.1 
Protein RefSeq:   
NP_001161870.1 
BRENDA:   
Kinetic info.
OMIM number:   
605634
GeneCards database:   
SLC35A1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     CMP-Neu5Ac [cyto] or CMP-Sia [cyto]
Product:  
     CMP-Neu5Ac [Golgi] or CMP-Sia [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-137 786-793 -0.532 98.0 -0.19 88.0 con
hsa-miR-1271-5p 353-360 -0.523 99.0 -0.519 99.0 con
hsa-miR-183-5p.2 352-359 -0.52 99.0 -0.516 99.0 con
hsa-miR-96-5p 353-360 -0.502 99.0 -0.498 99.0 con
hsa-miR-205-5p 219-226 -0.493 99.0 -0.493 99.0 con
hsa-miR-8485 237-244 -0.474 99.0 -0.474 99.0 noncon
hsa-miR-183-5p.1 617-623 -0.456 99.0 -0.453 99.0 con
hsa-miR-4433b-5p 330-337 -0.452 98.0 -0.449 99.0 noncon
hsa-miR-5186 64-71 -0.434 99.0 -0.434 99.0 noncon
hsa-miR-3143 767-774 -0.413 99.0 -0.151 95.0 noncon
hsa-miR-6738-3p 486-493 -0.412 98.0 -0.409 99.0 noncon
hsa-miR-5001-3p 485-492 -0.39 98.0 -0.387 98.0 noncon
hsa-miR-411-5p.1 201-208 -0.385 99.0 -0.385 99.0 noncon
hsa-miR-5707 143-149 -0.385 95.0 -0.385 96.0 noncon
hsa-miR-2682-3p 482-489 -0.381 98.0 -0.378 98.0 noncon
hsa-miR-6506-3p 275-281 -0.375 92.0 -0.373 95.0 noncon
hsa-miR-561-3p 792-799 -0.365 99.0 -0.135 97.0 noncon
hsa-miR-4672 519-526 -0.365 99.0 -0.363 99.0 noncon
hsa-miR-6781-3p 482-489 -0.36 98.0 -0.358 98.0 noncon
hsa-miR-214-5p 497-503 -0.359 98.0 -0.357 98.0 noncon
hsa-miR-106b-3p 114-120 -0.349 91.0 -0.349 93.0 noncon
hsa-miR-4531 422-429 -0.348 98.0 -0.346 99.0 noncon
hsa-miR-496.1 310-317 -0.346 96.0 -0.344 97.0 noncon
hsa-miR-1301-5p 50-56 -0.343 97.0 -0.343 98.0 noncon
hsa-miR-3680-5p 590-597 -0.336 98.0 -0.334 99.0 noncon
hsa-miR-6502-5p 50-56 -0.325 96.0 -0.325 97.0 noncon
hsa-miR-4719 741-748 -0.323 99.0 -0.121 96.0 noncon
hsa-miR-124-3p.2 55-61 -0.322 92.0 -0.322 94.0 con
hsa-miR-4742-3p 170-177 -0.317 97.0 -0.317 98.0 noncon
hsa-miR-3692-3p 125-132 -0.316 97.0 -0.316 98.0 noncon
hsa-miR-4646-3p 331-337 -0.313 95.0 -0.311 96.0 noncon
hsa-miR-488-5p 628-634 -0.313 97.0 -0.311 98.0 noncon
hsa-miR-3941 238-244 -0.306 98.0 -0.306 99.0 noncon
hsa-miR-4294 16-22 -0.303 95.0 -0.303 96.0 noncon
hsa-miR-8068 137-144 -0.3 95.0 -0.3 97.0 noncon
hsa-miR-3173-3p 414-421 -0.295 97.0 -0.293 98.0 noncon
hsa-miR-3936 582-588 -0.294 96.0 -0.292 97.0 noncon
hsa-miR-6891-5p 414-421 -0.285 97.0 -0.283 97.0 noncon
hsa-miR-6822-3p 51-57 -0.285 96.0 -0.285 97.0 noncon
hsa-miR-1-5p 712-718 -0.283 97.0 -0.281 97.0 noncon
hsa-miR-1-5p 264-270 -0.279 96.0 -0.279 97.0 noncon
hsa-miR-5590-5p 103-109 -0.278 96.0 -0.278 97.0 noncon
hsa-miR-3936 597-603 -0.274 95.0 -0.272 97.0 noncon
hsa-miR-4798-3p 591-597 -0.273 97.0 -0.271 98.0 noncon
hsa-miR-141-3p 754-760 -0.272 97.0 -0.103 87.0 noncon
hsa-miR-511-3p 660-666 -0.271 96.0 -0.269 97.0 noncon
hsa-miR-548k 697-703 -0.269 98.0 -0.267 99.0 noncon
hsa-miR-548av-5p 697-703 -0.269 98.0 -0.267 99.0 noncon
hsa-miR-1237-3p 70-76 -0.268 97.0 -0.268 98.0 noncon
hsa-miR-652-5p 344-350 -0.267 97.0 -0.265 98.0 noncon
hsa-miR-4461 733-740 -0.266 96.0 -0.101 87.0 noncon
hsa-miR-3609 689-695 -0.263 98.0 -0.261 99.0 noncon
hsa-miR-200a-3p 754-760 -0.261 97.0 -0.099 87.0 noncon
hsa-miR-135b-5p 359-365 -0.257 93.0 -0.255 95.0 con
hsa-miR-135a-5p 359-365 -0.257 93.0 -0.255 95.0 con
hsa-miR-7153-3p 296-302 -0.257 96.0 -0.255 97.0 noncon
hsa-miR-491-3p 79-85 -0.256 92.0 -0.256 95.0 noncon
hsa-miR-506-3p 55-61 -0.256 91.0 -0.256 94.0 con
hsa-miR-4709-5p 723-729 -0.252 97.0 -0.25 98.0 noncon