FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35A3



General Information
Gene Symbol:   
SLC35A3
Protein name:   
UDP-N-acetylglucosamine transporter
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

UDP-GlcNAc [cyto] → UDP-GlcNAc [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• One of three UDP-GlcNAc antiporters (SLC35A3, ALC35B4, SLC35D2). It does not transport other nucleotide sugars

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-5619083
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9Y2D2 
NCBI GeneID:   
23443
GlyMap GeneID:   
23443
DNA aRefSeq:   
NM_001271684.1 
Protein RefSeq:   
NP_001258613.1 
BRENDA:   
Kinetic info.
OMIM number:   
605632
GeneCards database:   
SLC35A3
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     UDP-GlcNAc [cyto]
Product:  
     UDP-GlcNAc [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4727-3p 48-55 -0.503 98.0 -0.503 98.0 noncon
hsa-miR-4641 4070-4077 -0.477 98.0 -0.246 92.0 noncon
hsa-miR-371b-3p 96-103 -0.463 99.0 -0.463 99.0 noncon
hsa-miR-450b-3p 27-34 -0.462 99.0 -0.462 99.0 noncon
hsa-miR-769-3p 27-34 -0.451 99.0 -0.451 99.0 noncon
hsa-miR-4308 262-269 -0.441 99.0 -0.441 99.0 noncon
hsa-miR-383-5p.1 170-177 -0.431 98.0 -0.431 98.0 con
hsa-miR-214-5p 3111-3118 -0.428 99.0 -0.222 96.0 noncon
hsa-miR-5197-5p 885-892 -0.417 98.0 -0.415 99.0 noncon
hsa-miR-496.1 922-929 -0.402 98.0 -0.277 96.0 con
hsa-miR-490-3p 3942-3949 -0.391 99.0 -0.204 96.0 noncon
hsa-miR-3189-5p 93-100 -0.39 98.0 -0.39 99.0 noncon
hsa-miR-1184 337-344 -0.382 98.0 -0.382 99.0 noncon
hsa-miR-432-3p 2576-2583 -0.379 98.0 -0.199 91.0 noncon
hsa-miR-4455 2172-2179 -0.377 94.0 -0.198 83.0 noncon
hsa-miR-3607-5p 462-469 -0.372 99.0 -0.372 99.0 noncon
hsa-miR-1263 2644-2651 -0.367 96.0 -0.193 88.0 noncon
hsa-miR-1273a 2241-2248 -0.367 94.0 -0.193 80.0 noncon
hsa-miR-455-3p.2 2745-2752 -0.361 99.0 -0.19 96.0 noncon
hsa-miR-18b-5p 3979-3985 -0.357 97.0 -0.188 93.0 con
hsa-miR-18a-5p 3979-3985 -0.357 97.0 -0.188 93.0 con
hsa-miR-6868-3p 278-285 -0.348 98.0 -0.348 98.0 noncon
hsa-miR-6719-3p 381-388 -0.347 98.0 -0.347 99.0 noncon
hsa-miR-569 4146-4153 -0.347 99.0 -0.183 95.0 noncon
hsa-miR-190a-5p 3745-3752 -0.345 96.0 -0.182 91.0 con
hsa-miR-8082 4225-4232 -0.345 97.0 -0.182 89.0 noncon
hsa-miR-657 34-41 -0.341 98.0 -0.341 98.0 noncon
hsa-miR-606 3955-3962 -0.34 98.0 -0.179 94.0 noncon
hsa-miR-190b 3745-3752 -0.337 96.0 -0.178 90.0 con
hsa-miR-4735-3p 3979-3985 -0.336 97.0 -0.177 92.0 con
hsa-miR-4633-5p 3114-3121 -0.335 94.0 -0.177 87.0 noncon
hsa-miR-3941 876-883 -0.335 99.0 -0.335 99.0 noncon
hsa-miR-139-5p 4060-4067 -0.329 98.0 -0.174 95.0 noncon
hsa-miR-218-5p 3095-3102 -0.326 96.0 -0.172 90.0 noncon
hsa-miR-3935 959-966 -0.325 96.0 -0.177 89.0 noncon
hsa-miR-205-5p 584-591 -0.322 98.0 -0.322 98.0 noncon
hsa-miR-4451 1424-1431 -0.32 93.0 -0.169 84.0 noncon
hsa-miR-199b-5p 1674-1681 -0.319 95.0 -0.169 90.0 con
hsa-miR-3912-5p 3067-3074 -0.319 97.0 -0.169 92.0 noncon
hsa-miR-199a-5p 1674-1681 -0.319 95.0 -0.169 90.0 con
hsa-miR-8066 3846-3853 -0.311 98.0 -0.165 95.0 noncon
hsa-miR-4661-3p 4328-4334 -0.304 95.0 -0.158 88.0 noncon
hsa-miR-1257 3843-3850 -0.303 97.0 -0.161 90.0 noncon
hsa-miR-6748-5p 2174-2181 -0.302 92.0 -0.16 78.0 noncon
hsa-miR-6513-5p 28-35 -0.301 98.0 -0.301 99.0 noncon
hsa-miR-500a-5p 914-921 -0.301 98.0 -0.209 97.0 noncon
hsa-miR-885-5p 789-796 -0.301 97.0 -0.301 98.0 noncon
hsa-miR-374c-3p 2782-2789 -0.3 96.0 -0.159 92.0 noncon
hsa-miR-10b-3p 167-174 -0.299 98.0 -0.299 98.0 noncon
hsa-miR-3074-5p 39-46 -0.295 98.0 -0.295 99.0 noncon
hsa-miR-3191-5p 774-781 -0.295 97.0 -0.295 98.0 noncon
hsa-miR-4654 46-52 -0.294 96.0 -0.294 97.0 noncon
hsa-miR-8061 664-671 -0.293 97.0 -0.293 98.0 noncon
hsa-miR-8485 875-882 -0.292 97.0 -0.292 98.0 noncon
hsa-miR-4291 734-741 -0.29 96.0 -0.29 97.0 noncon
hsa-miR-3660 644-651 -0.289 97.0 -0.289 97.0 noncon
hsa-miR-4501 3636-3643 -0.288 97.0 -0.153 93.0 noncon
hsa-miR-6853-3p 1021-1028 -0.288 96.0 -0.158 91.0 noncon
hsa-miR-8083 845-851 -0.286 97.0 -0.286 98.0 noncon
hsa-miR-4645-3p 4266-4272 -0.286 95.0 -0.152 86.0 noncon
hsa-miR-4766-3p 591-598 -0.283 97.0 -0.283 98.0 noncon
hsa-miR-6888-3p 1819-1826 -0.282 96.0 -0.15 91.0 noncon
hsa-miR-568 565-572 -0.282 98.0 -0.282 98.0 noncon
hsa-miR-301a-5p 646-653 -0.281 98.0 -0.281 99.0 noncon
hsa-miR-124-3p.1 4005-4011 -0.279 94.0 -0.148 90.0 con
hsa-miR-183-5p.2 3429-3436 -0.279 93.0 -0.148 86.0 con
hsa-miR-7975 100-107 -0.279 96.0 -0.279 97.0 noncon
hsa-miR-203a-3p.1 537-544 -0.279 98.0 -0.279 98.0 con
hsa-miR-4708-3p 4007-4013 -0.278 93.0 -0.148 86.0 noncon
hsa-miR-4534 4225-4232 -0.277 97.0 -0.147 91.0 noncon
hsa-miR-301b-5p 646-653 -0.273 98.0 -0.273 99.0 noncon
hsa-miR-610 2844-2851 -0.273 95.0 -0.146 84.0 noncon
hsa-miR-2054 4169-4176 -0.273 98.0 -0.146 95.0 noncon
hsa-miR-3140-3p 4174-4181 -0.272 98.0 -0.145 93.0 noncon
hsa-miR-892a 3511-3518 -0.272 96.0 -0.145 92.0 noncon
hsa-miR-103b 3170-3176 -0.27 93.0 -0.144 87.0 noncon
hsa-miR-4318 2177-2184 -0.27 96.0 -0.144 90.0 noncon
hsa-miR-16-1-3p 3729-3736 -0.269 97.0 -0.143 93.0 noncon
hsa-miR-585-5p 3408-3415 -0.267 92.0 -0.142 82.0 noncon
hsa-miR-3147 2667-2674 -0.265 95.0 -0.141 90.0 noncon
hsa-miR-6832-5p 3713-3720 -0.262 92.0 -0.14 81.0 noncon
hsa-miR-1293 2687-2693 -0.262 95.0 -0.14 88.0 noncon
hsa-miR-610 4131-4137 -0.261 94.0 -0.139 83.0 noncon
hsa-miR-376a-2-5p 1059-1066 -0.261 96.0 -0.139 91.0 noncon
hsa-miR-4765 3824-3831 -0.26 96.0 -0.139 91.0 noncon
hsa-miR-6773-3p 1110-1117 -0.258 94.0 -0.138 89.0 noncon
hsa-miR-3651 3169-3175 -0.257 90.0 -0.137 84.0 noncon
hsa-miR-519d-5p 967-974 -0.257 96.0 -0.141 92.0 noncon
hsa-miR-1284 3778-3784 -0.257 93.0 -0.137 84.0 noncon
hsa-miR-3912-5p 4416-4422 -0.256 95.0 -0.132 88.0 noncon
hsa-miR-3674 1061-1067 -0.255 92.0 -0.136 83.0 noncon
hsa-miR-1287-5p 4500-4506 -0.255 96.0 -0.008 41.0 noncon
hsa-miR-5699-3p 3110-3116 -0.254 94.0 -0.136 88.0 noncon
hsa-miR-3650 2058-2065 -0.253 93.0 -0.135 87.0 noncon
hsa-miR-515-5p 968-975 -0.251 97.0 -0.138 91.0 noncon
hsa-miR-519e-5p 968-975 -0.251 97.0 -0.138 91.0 noncon
hsa-miR-1205 36-42 -0.25 97.0 -0.25 97.0 noncon