FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35B4



General Information
Gene Symbol:   
SLC35B4
Protein name:   
UDP-xylose and UDP-N-acetylglucosamine transporter
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

UDP-Xyl [Cyto] or UDP-GlcNAc [Cyto] → UDP-Xyl [Golgi] or UDP-GlcNAc [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• UDP-xylose is made within the lumen of the ER or Golgi by UDP-xylose synthase (UXS)
• There is a transporter for this nucleotide-sugar, that transports both UDP-Xyl and UDP-GlcNAc

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-727802
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q969S0 
NCBI GeneID:   
84912
GlyMap GeneID:   
84912
DNA aRefSeq:   
NM_032826.4 
Protein RefSeq:   
NP_116215.1 
BRENDA:   
Kinetic info.
OMIM number:   
610923
GeneCards database:   
SLC35B4
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     UDP-Xyl [Cyto] or UDP-GlcNAc [Cyto]
Product:  
     UDP-Xyl [Golgi] or UDP-GlcNAc [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 60 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3195 5105-5112 -0.638 96.0 -0.109 50.0 noncon
hsa-miR-3177-3p 109-116 -0.545 97.0 -0.545 98.0 noncon
hsa-miR-6738-5p 181-188 -0.478 99.0 -0.478 99.0 noncon
hsa-miR-5194 181-188 -0.465 99.0 -0.465 99.0 noncon
hsa-miR-4446-3p 187-194 -0.455 99.0 -0.455 99.0 noncon
hsa-miR-7112-5p 1225-1232 -0.434 96.0 -0.415 96.0 noncon
hsa-miR-4741 227-234 -0.427 99.0 -0.426 99.0 noncon
hsa-miR-4746-3p 1118-1125 -0.405 96.0 -0.387 97.0 noncon
hsa-miR-1914-3p 181-188 -0.389 99.0 -0.389 99.0 noncon
hsa-miR-2909 189-196 -0.384 98.0 -0.384 98.0 noncon
hsa-miR-182-5p 5489-5496 -0.367 97.0 -0.049 60.0 con
hsa-miR-6887-3p 131-138 -0.366 95.0 -0.366 96.0 noncon
hsa-miR-4675 227-234 -0.362 99.0 -0.361 99.0 noncon
hsa-miR-6861-3p 1437-1444 -0.361 96.0 -0.345 96.0 noncon
hsa-miR-6802-5p 1918-1925 -0.359 95.0 -0.342 96.0 noncon
hsa-miR-153-3p 640-647 -0.355 97.0 -0.34 98.0 con
hsa-miR-6787-3p 5345-5352 -0.331 98.0 -0.057 84.0 noncon
hsa-miR-6752-3p 2412-2419 -0.327 96.0 -0.312 96.0 noncon
hsa-miR-1304-5p 4216-4223 -0.32 96.0 -0.242 95.0 noncon
hsa-miR-6734-3p 545-552 -0.318 96.0 -0.305 97.0 noncon
hsa-miR-2116-3p 5463-5470 -0.317 98.0 -0.055 86.0 noncon
hsa-miR-4645-5p 3985-3992 -0.316 98.0 -0.278 98.0 noncon
hsa-miR-4260 2471-2478 -0.307 95.0 -0.293 96.0 noncon
hsa-miR-5196-5p 3769-3776 -0.306 96.0 -0.269 95.0 noncon
hsa-miR-6728-3p 5444-5451 -0.303 97.0 -0.053 78.0 noncon
hsa-miR-548s 2967-2974 -0.303 98.0 -0.289 98.0 noncon
hsa-miR-4735-3p 4663-4670 -0.303 96.0 -0.057 78.0 noncon
hsa-miR-4418 3179-3186 -0.301 98.0 -0.285 98.0 noncon
hsa-miR-1587 228-234 -0.3 96.0 -0.299 97.0 noncon
hsa-miR-6502-5p 2813-2820 -0.292 94.0 -0.278 95.0 noncon
hsa-miR-1301-5p 2813-2820 -0.287 95.0 -0.274 96.0 noncon
hsa-miR-767-3p 5442-5449 -0.286 97.0 -0.05 68.0 noncon
hsa-miR-18a-5p 4663-4670 -0.285 95.0 -0.054 79.0 noncon
hsa-miR-18b-5p 4663-4670 -0.285 95.0 -0.054 79.0 noncon
hsa-miR-6773-5p 2318-2324 -0.284 93.0 -0.271 94.0 noncon
hsa-miR-4786-5p 4043-4050 -0.283 96.0 -0.25 96.0 noncon
hsa-miR-3664-5p 1938-1945 -0.282 98.0 -0.269 98.0 noncon
hsa-miR-3188 4214-4221 -0.281 97.0 -0.213 96.0 noncon
hsa-miR-6734-5p 182-188 -0.279 91.0 -0.279 94.0 noncon
hsa-miR-4747-5p 3769-3776 -0.274 94.0 -0.242 94.0 noncon
hsa-miR-4673 3985-3992 -0.274 97.0 -0.242 97.0 noncon
hsa-miR-509-3-5p 3179-3186 -0.272 98.0 -0.258 98.0 noncon
hsa-miR-4301 5377-5383 -0.271 97.0 -0.047 66.0 noncon
hsa-miR-4667-3p 5331-5338 -0.27 95.0 -0.047 68.0 noncon
hsa-miR-1915-3p 2481-2488 -0.269 97.0 -0.257 98.0 noncon
hsa-miR-363-5p 4014-4020 -0.269 94.0 -0.237 93.0 noncon
hsa-miR-4734 3312-3318 -0.268 90.0 -0.254 91.0 noncon
hsa-miR-5690 2504-2511 -0.265 97.0 -0.253 98.0 noncon
hsa-miR-509-5p 3179-3186 -0.264 97.0 -0.25 98.0 noncon
hsa-miR-4513 452-459 -0.262 94.0 -0.251 96.0 noncon
hsa-miR-6745 4014-4020 -0.261 93.0 -0.23 93.0 noncon
hsa-miR-622 153-160 -0.26 96.0 -0.26 97.0 noncon
hsa-miR-671-5p 5419-5426 -0.259 93.0 -0.046 67.0 noncon
hsa-miR-548v 4086-4093 -0.258 92.0 -0.228 92.0 noncon
hsa-miR-455-5p 5028-5034 -0.257 92.0 -0.049 71.0 noncon
hsa-miR-3126-3p 3799-3806 -0.254 94.0 -0.224 95.0 noncon
hsa-miR-96-5p 5490-5496 -0.253 93.0 -0.035 66.0 con
hsa-miR-4656 186-192 -0.251 94.0 -0.251 96.0 noncon