FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35D1



General Information
Gene Symbol:   
SLC35D1
Protein name:   
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

UDP-GlcA [cyto] or UDP-GalNAc [cyto] or UDP-GlcA [cyto] or UDP-GalNAc [cyto] → UDP-GlcA [ER] or UDP-GalNAc [ER] or UDP-GlcA [Golgi] or UDP-GalNAc [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• UDP-GalNAc & UDP-GlcA transporter

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-173599
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9NTN3 
NCBI GeneID:   
23169
GlyMap GeneID:   
23169
DNA aRefSeq:   
NM_015139.2 
Protein RefSeq:   
NP_055954.1 
BRENDA:   
Kinetic info.
OMIM number:   
610804
GeneCards database:   
SLC35D1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     UDP-GlcA [cyto] or UDP-GalNAc [cyto] or UDP-GlcA [cyto] or UDP-GalNAc [cyto]
Product:  
     UDP-GlcA [ER] or UDP-GalNAc [ER] or UDP-GlcA [Golgi] or UDP-GalNAc [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000235345 AR ZNF770 HLF SOX2 TAL1 IKZF1 PPARG ASCL1 SMARCE1 PRDM6 HMG20A MAFK FEZF1 TCF3 RUNX1 SCRT1 NFIL3 GATAD2A ZNF324 ZNF263 NR2F6 REST NFE2 KLF9 KLF9 GLIS1 EBF1 SMAD4 NRF1 ZNF574 KLF4 KLF4 RCOR1 ZSCAN22 CREB1 MAZ PATZ1 PATZ1 POU5F1 POU5F1 SMAD2 SOX2 ARNT VEZF1 NFYA NFKB1 ZBTB14 MYCN EOMES FOSL1 E2F6 CEBPB FOXP1 MAX ZBTB26 ATF1 CREB1 CREB1 MEIS2 MEIS2 E2F1 ZBTB2 ZBTB2 RUNX3 ZBTB16 YY1 MAF SMAD5 NFE2 NFE2 SMARCC1 TBX5 MAX ERG ATF2 NR2F2 SOX2 ZBTB17 ZBTB17 ZKSCAN8 REST JUNB JUNB KDM5C SMAD1 MAX TEAD1 HMG20A GATAD2A NFYC NFYC HOMEZ ZBTB11 TFAP2C ZBTB20 ZBTB20 ZBTB20 RXRB GATA2 ZNF652 SOX5 SP3 RCOR1 DMAP1 NR2F6 ARID4B TBX3 ZNF335 ZNF335 ZNF335 KAT8 HMG20B HMG20B RCOR2 RCOR2 RCOR2 NFIA NFIA NR2F2 NR2F2 NR2F2 NR2F2 SMAD4 TCF12 CEBPG CEBPG CEBPG CEBPG THAP11 THAP11 NR2F1 NR2F1 ZNF18 GLIS1 TAL1 TAL1 TAL1 ZNF48 HNF4G HNF4G HNF4G TEAD4 TEAD4 BACH1 CREB1 RFXANK MITF PPARG MXD4 MXD4 SP5 ZBTB26 ZNF792 ZNF792 SP4 SP4 SP2 IRF1 USF2 KLF12 BCL6 ZNF391 ZNF391 KLF15 FOSL2 ZIC2 ZFP64 NONO KLF9 KLF4 E2F4 E2F6 IKZF1 IKZF1 ZNF618 TCF7L1 PAX5 TFAP4 MAZ ZBTB26 APC ZBTB18
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6716-3p 3636-3643 -0.62 98.0 -0.123 63.0 noncon
hsa-miR-219a-1-3p 43-50 -0.483 99.0 -0.483 99.0 noncon
hsa-miR-4423-3p 4913-4920 -0.478 98.0 -0.068 74.0 noncon
hsa-miR-1911-3p 3681-3688 -0.455 98.0 -0.081 79.0 noncon
hsa-miR-5582-5p 4912-4919 -0.437 99.0 -0.063 72.0 noncon
hsa-miR-212-5p 504-511 -0.431 98.0 -0.378 98.0 noncon
hsa-miR-122-3p 4095-4102 -0.429 97.0 -0.062 57.0 noncon
hsa-miR-6792-3p 94-101 -0.419 98.0 -0.419 99.0 noncon
hsa-miR-4716-3p 4010-4017 -0.416 97.0 -0.073 57.0 noncon
hsa-miR-3605-3p 3110-3117 -0.402 95.0 -0.084 69.0 noncon
hsa-miR-4660 332-339 -0.389 98.0 -0.355 97.0 noncon
hsa-miR-6506-3p 19-25 -0.388 93.0 -0.388 95.0 noncon
hsa-miR-4743-5p 4345-4352 -0.384 97.0 -0.056 37.0 noncon
hsa-miR-6873-3p 164-171 -0.378 98.0 -0.375 98.0 noncon
hsa-miR-6515-3p 161-168 -0.374 99.0 -0.374 99.0 noncon
hsa-miR-6794-5p 4010-4017 -0.371 96.0 -0.066 54.0 noncon
hsa-miR-4462 3717-3724 -0.37 93.0 -0.067 56.0 noncon
hsa-miR-4792 4112-4119 -0.369 97.0 -0.054 72.0 noncon
hsa-miR-6767-3p 2417-2424 -0.367 96.0 -0.078 77.0 noncon
hsa-miR-3622a-3p 4887-4894 -0.365 99.0 -0.054 79.0 noncon
hsa-miR-593-3p 69-76 -0.363 98.0 -0.363 98.0 noncon
hsa-miR-4691-5p 94-101 -0.354 98.0 -0.354 99.0 noncon
hsa-miR-454-3p 114-120 -0.353 98.0 -0.353 98.0 con
hsa-miR-378j 5001-5008 -0.343 97.0 -0.008 41.0 noncon
hsa-miR-3622b-3p 4887-4894 -0.341 99.0 -0.05 80.0 noncon
hsa-miR-4682 45-52 -0.339 98.0 -0.339 98.0 noncon
hsa-miR-130b-3p 114-120 -0.339 97.0 -0.339 98.0 con
hsa-miR-4470 348-355 -0.334 98.0 -0.305 98.0 noncon
hsa-miR-4758-3p 538-544 -0.333 96.0 -0.293 96.0 noncon
hsa-miR-4474-5p 4995-5002 -0.332 96.0 -0.008 42.0 noncon
hsa-miR-4768-5p 165-172 -0.33 97.0 -0.327 97.0 noncon
hsa-miR-3666 114-120 -0.328 97.0 -0.328 98.0 con
hsa-miR-6733-3p 73-80 -0.326 97.0 -0.326 98.0 noncon
hsa-miR-6839-5p 5001-5008 -0.325 97.0 -0.008 43.0 noncon
hsa-miR-3649 1114-1121 -0.324 95.0 -0.069 66.0 noncon
hsa-miR-1295a 28-34 -0.324 97.0 -0.324 98.0 noncon
hsa-miR-301a-3p 114-120 -0.317 97.0 -0.317 98.0 con
hsa-miR-130a-3p 114-120 -0.317 97.0 -0.317 98.0 con
hsa-miR-301b-3p 114-120 -0.317 97.0 -0.317 98.0 con
hsa-miR-3126-3p 3306-3313 -0.316 97.0 -0.068 80.0 noncon
hsa-miR-1273a 4071-4078 -0.313 90.0 -0.047 41.0 noncon
hsa-miR-6833-3p 165-172 -0.312 97.0 -0.309 97.0 noncon
hsa-miR-6739-3p 3952-3959 -0.309 96.0 -0.057 74.0 noncon
hsa-miR-6072 969-975 -0.302 96.0 -0.065 78.0 noncon
hsa-miR-8065 63-70 -0.299 92.0 -0.299 95.0 noncon
hsa-miR-3135a 4132-4138 -0.295 91.0 -0.044 55.0 noncon
hsa-miR-19a-3p 113-119 -0.295 94.0 -0.295 95.0 con
hsa-miR-19b-3p 113-119 -0.295 94.0 -0.295 95.0 con
hsa-miR-4295 114-120 -0.295 96.0 -0.295 97.0 con
hsa-miR-3682-3p 488-495 -0.286 96.0 -0.252 96.0 noncon
hsa-miR-4530 412-419 -0.284 96.0 -0.26 97.0 noncon
hsa-miR-6760-3p 268-275 -0.283 97.0 -0.259 97.0 noncon
hsa-miR-107 955-962 -0.282 96.0 -0.061 72.0 noncon
hsa-miR-103a-3p 955-962 -0.282 96.0 -0.061 72.0 noncon
hsa-miR-4695-3p 1630-1637 -0.281 95.0 -0.061 69.0 noncon
hsa-miR-3927-3p 3934-3941 -0.276 94.0 -0.052 62.0 noncon
hsa-miR-1266-5p 326-333 -0.275 96.0 -0.252 97.0 noncon
hsa-miR-4648 1116-1123 -0.272 95.0 -0.059 75.0 noncon
hsa-miR-3928-5p 360-367 -0.265 96.0 -0.243 96.0 noncon
hsa-miR-4715-5p 352-358 -0.259 92.0 -0.237 94.0 noncon
hsa-miR-6072 1110-1116 -0.259 94.0 -0.056 76.0 noncon
hsa-miR-4530 3894-3901 -0.259 96.0 -0.049 73.0 noncon
hsa-miR-6866-5p 3836-3842 -0.258 90.0 -0.048 68.0 noncon
hsa-miR-6862-3p 656-663 -0.256 93.0 -0.056 73.0 noncon
hsa-miR-6891-3p 1110-1116 -0.256 94.0 -0.056 76.0 noncon
hsa-miR-875-5p 4875-4881 -0.253 94.0 -0.038 72.0 noncon
hsa-miR-622 220-226 -0.25 95.0 -0.248 96.0 noncon
hsa-miR-4441 3621-3628 -0.25 95.0 -0.054 72.0 noncon