FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35D2



General Information
Gene Symbol:   
SLC35D2
Protein name:   
UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

UDP-GlcNAc [cyto] or UDP-Glc [cyto] or GDP-Man [cyto] → UDP-GlcNAc [Golgi] or UDP-Glc [Golgi] or GDP-Man [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• Antiporter transporting nucleotide sugars UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) from cytosol into Golgi, in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars).

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2022854
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q76EJ3 
NCBI GeneID:   
11046
GlyMap GeneID:   
11046
DNA aRefSeq:   
NM_001286990.1 
Protein RefSeq:   
NP_001273919.1 
BRENDA:   
Kinetic info.
OMIM number:   
609182
GeneCards database:   
SLC35D2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     UDP-GlcNAc [cyto] or UDP-Glc [cyto] or GDP-Man [cyto]
Product:  
     UDP-GlcNAc [Golgi] or UDP-Glc [Golgi] or GDP-Man [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-let-7d-5p 141-148 -0.676 99.0 -0.676 99.0 con
hsa-miR-4500 141-148 -0.634 99.0 -0.634 99.0 con
hsa-let-7g-5p 141-148 -0.634 99.0 -0.634 99.0 con
hsa-let-7i-5p 141-148 -0.634 99.0 -0.634 99.0 con
hsa-let-7b-5p 141-148 -0.626 99.0 -0.626 99.0 con
hsa-let-7a-5p 141-148 -0.626 99.0 -0.626 99.0 con
hsa-let-7f-5p 141-148 -0.626 99.0 -0.626 99.0 con
hsa-miR-98-5p 141-148 -0.626 99.0 -0.626 99.0 con
hsa-let-7e-5p 141-148 -0.626 99.0 -0.626 99.0 con
hsa-let-7c-5p 141-148 -0.626 99.0 -0.626 99.0 con
hsa-miR-548au-3p 445-452 -0.624 99.0 -0.624 99.0 noncon
hsa-miR-4458 141-148 -0.604 99.0 -0.604 99.0 con
hsa-miR-3649 373-380 -0.537 98.0 -0.537 99.0 noncon
hsa-miR-6851-3p 390-397 -0.524 99.0 -0.524 99.0 noncon
hsa-miR-4505 377-384 -0.514 99.0 -0.514 99.0 noncon
hsa-miR-376c-3p 529-536 -0.495 99.0 -0.042 62.0 noncon
hsa-miR-598-5p 2016-2023 -0.475 98.0 -0.006 21.0 noncon
hsa-miR-140-3p.1 202-209 -0.469 99.0 -0.469 99.0 noncon
hsa-miR-383-5p.1 344-351 -0.451 98.0 -0.451 99.0 noncon
hsa-miR-5787 377-384 -0.444 99.0 -0.444 99.0 noncon
hsa-miR-3129-3p 438-445 -0.435 99.0 -0.435 99.0 noncon
hsa-miR-5583-5p 438-445 -0.419 99.0 -0.419 99.0 noncon
hsa-miR-5584-5p 495-502 -0.412 99.0 -0.131 90.0 noncon
hsa-miR-5705 1545-1552 -0.405 94.0 -0.005 22.0 noncon
hsa-miR-6842-3p 378-385 -0.402 98.0 -0.402 99.0 noncon
hsa-miR-4793-5p 153-160 -0.393 99.0 -0.393 99.0 noncon
hsa-miR-4699-3p 511-518 -0.393 99.0 -0.125 95.0 noncon
hsa-miR-6868-5p 447-453 -0.391 98.0 -0.173 90.0 noncon
hsa-miR-3923 2389-2396 -0.377 98.0 -0.005 24.0 noncon
hsa-miR-2392 1767-1774 -0.354 98.0 -0.004 41.0 noncon
hsa-miR-377-5p 2352-2359 -0.353 98.0 -0.004 35.0 noncon
hsa-miR-526b-5p 173-180 -0.35 98.0 -0.35 98.0 noncon
hsa-miR-520g-5p 1831-1838 -0.35 97.0 -0.004 37.0 noncon
hsa-miR-7702 427-433 -0.341 96.0 -0.341 98.0 noncon
hsa-miR-5584-5p 2583-2590 -0.338 99.0 -0.004 35.0 noncon
hsa-miR-6739-5p 494-500 -0.338 98.0 -0.116 88.0 noncon
hsa-miR-5002-3p 167-173 -0.335 95.0 -0.335 97.0 noncon
hsa-miR-5585-3p 2664-2671 -0.334 99.0 0.0 0.0 noncon
hsa-miR-193b-3p 393-399 -0.333 95.0 -0.333 96.0 noncon
hsa-miR-125b-2-3p 27-34 -0.331 98.0 -0.331 99.0 noncon
hsa-miR-424-5p 2160-2167 -0.331 97.0 -0.004 32.0 noncon
hsa-miR-6733-5p 494-500 -0.327 98.0 -0.112 88.0 noncon
hsa-miR-497-5p 2160-2167 -0.315 96.0 -0.004 31.0 noncon
hsa-miR-885-5p 328-334 -0.315 97.0 -0.315 98.0 noncon
hsa-miR-5680 525-532 -0.31 99.0 -0.101 98.0 noncon
hsa-miR-939-3p 2473-2480 -0.305 96.0 -0.004 48.0 noncon
hsa-miR-328-3p 391-397 -0.304 95.0 -0.304 97.0 noncon
hsa-miR-6838-5p 2160-2167 -0.304 95.0 -0.004 27.0 noncon
hsa-miR-3653-3p 2648-2655 -0.304 99.0 -0.004 54.0 noncon
hsa-miR-195-5p 2160-2167 -0.302 95.0 -0.004 30.0 noncon
hsa-miR-16-5p 2160-2167 -0.302 95.0 -0.004 31.0 noncon
hsa-miR-15b-5p 2160-2167 -0.302 95.0 -0.004 28.0 noncon
hsa-miR-3672 170-177 -0.3 98.0 -0.3 98.0 noncon
hsa-miR-193a-3p 393-399 -0.3 93.0 -0.3 95.0 noncon
hsa-miR-6804-3p 1087-1094 -0.298 94.0 -0.004 28.0 noncon
hsa-miR-15a-5p 2160-2167 -0.294 95.0 -0.004 29.0 noncon
hsa-miR-892b 449-455 -0.288 94.0 -0.13 84.0 noncon
hsa-miR-873-3p 169-176 -0.288 98.0 -0.288 98.0 noncon
hsa-miR-4283 252-259 -0.287 93.0 -0.287 94.0 noncon
hsa-miR-4523 241-247 -0.28 92.0 -0.28 94.0 noncon
hsa-miR-6798-5p 100-106 -0.28 94.0 -0.28 95.0 noncon
hsa-miR-4665-3p 1543-1549 -0.278 92.0 -0.004 20.0 noncon
hsa-miR-196b-5p 140-146 -0.276 94.0 -0.276 96.0 noncon
hsa-miR-196a-5p 140-146 -0.276 94.0 -0.276 96.0 noncon
hsa-miR-6510-5p 867-874 -0.272 96.0 -0.004 39.0 noncon
hsa-miR-6832-5p 1556-1563 -0.272 93.0 -0.004 24.0 noncon
hsa-miR-6086 2352-2359 -0.267 98.0 -0.004 43.0 noncon
hsa-miR-1301-3p 1361-1368 -0.266 95.0 -0.004 34.0 noncon
hsa-miR-151a-3p 427-433 -0.265 93.0 -0.265 96.0 noncon
hsa-miR-4704-3p 31-37 -0.264 95.0 -0.264 96.0 noncon
hsa-miR-363-5p 96-102 -0.262 93.0 -0.262 95.0 noncon
hsa-miR-4695-5p 964-971 -0.258 95.0 -0.003 45.0 noncon
hsa-miR-580-5p 522-528 -0.256 98.0 -0.084 92.0 noncon
hsa-miR-3682-3p 503-509 -0.255 95.0 -0.084 76.0 noncon
hsa-miR-654-3p 414-420 -0.254 96.0 -0.254 97.0 noncon
hsa-miR-548s 2632-2638 -0.254 97.0 -0.003 32.0 noncon
hsa-miR-526a 1832-1839 -0.253 95.0 -0.003 41.0 noncon
hsa-miR-518d-5p 1832-1839 -0.253 95.0 -0.003 41.0 noncon
hsa-miR-518f-5p 1832-1839 -0.253 95.0 -0.003 41.0 noncon
hsa-miR-520c-5p 1832-1839 -0.253 95.0 -0.003 41.0 noncon