GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
ARSB



General Information
Gene Symbol:   
ARSB
Protein name:   
Arylsulfatase B
Enzyme Class:   
CAZy Family:   
E.C. No:   
3.1.6.12
Organs:   
Reaction (SNFG):   

GalNAc(b1-4 [4S]) → GalNAc(b1-4)
Reaction (IUBMB):   
No specified reaction.
About

• Removes sulfate groups from chondroitin-4-sulfate(C4S) and regulates its degradation
• One of three human CS/DS exosulfatases: ARSB (4-O-sulfatase) (Bond et al., 1997), GALNS (6-O-sulfatase) (Rivera-Colon et al., 2012) and IDS (iduronate-2-O-sulfatase) (Demydchuk et al., 2017).

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-1660662
Related Database
Organism:   
Homo sapiens
Uniprot:   
P15848 
NCBI GeneID:   
411
GlyMap GeneID:   
411
DNA aRefSeq:   
NM_000046.3 
Protein RefSeq:   
NP_000037.2 
BRENDA:   
Kinetic info.
OMIM number:   
611542
GeneCards database:   
ARSB
Enzyme Specificity
Glycan Type:  
     GAG
Compartment:  
     
Substrate:  
     GalNAc(b1-4 [4S])
Product:  
     GalNAc(b1-4)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-563 3104-3111 -0.466 98.0 -0.094 78.0 noncon
hsa-miR-4524b-5p 4178-4185 -0.458 98.0 -0.038 62.0 noncon
hsa-miR-4524a-5p 4178-4185 -0.45 98.0 -0.038 61.0 noncon
hsa-miR-6795-5p 629-636 -0.444 94.0 -0.101 55.0 noncon
hsa-miR-6887-5p 629-636 -0.436 94.0 -0.1 54.0 noncon
hsa-miR-380-5p 3104-3111 -0.432 98.0 -0.088 78.0 noncon
hsa-miR-4727-3p 1193-1200 -0.391 96.0 -0.09 70.0 noncon
hsa-miR-1909-5p 1333-1340 -0.391 97.0 -0.09 82.0 noncon
hsa-miR-4290 1088-1095 -0.39 95.0 -0.09 70.0 noncon
hsa-miR-488-3p 22-29 -0.388 99.0 -0.388 99.0 noncon
hsa-miR-3191-5p 1250-1257 -0.376 98.0 -0.087 82.0 noncon
hsa-miR-7106-3p 405-412 -0.375 97.0 -0.235 93.0 noncon
hsa-miR-6730-5p 21-28 -0.37 99.0 -0.37 99.0 noncon
hsa-miR-6720-5p 303-310 -0.366 98.0 -0.23 95.0 noncon
hsa-miR-29c-3p 2076-2083 -0.36 95.0 -0.075 71.0 con
hsa-miR-29b-3p 2076-2083 -0.36 95.0 -0.075 71.0 con
hsa-miR-29a-3p 2076-2083 -0.36 95.0 -0.075 71.0 con
hsa-miR-646 4177-4184 -0.354 98.0 -0.031 62.0 noncon
hsa-miR-6512-3p 303-310 -0.35 98.0 -0.22 95.0 noncon
hsa-miR-637 2896-2903 -0.348 97.0 -0.073 72.0 noncon
hsa-miR-6881-5p 3315-3322 -0.336 93.0 -0.029 29.0 noncon
hsa-miR-3657 1946-1952 -0.332 95.0 -0.078 71.0 noncon
hsa-miR-628-5p 1918-1925 -0.328 97.0 -0.077 83.0 noncon
hsa-miR-3936 504-511 -0.318 97.0 -0.201 93.0 noncon
hsa-miR-642b-3p 3100-3107 -0.314 97.0 -0.066 81.0 noncon
hsa-miR-642a-3p 3100-3107 -0.314 97.0 -0.066 81.0 noncon
hsa-miR-671-5p 2957-2964 -0.31 95.0 -0.065 74.0 noncon
hsa-miR-4489 1289-1296 -0.309 97.0 -0.073 66.0 noncon
hsa-miR-3912-5p 1681-1688 -0.307 97.0 -0.073 78.0 noncon
hsa-miR-6077 4489-4496 -0.298 98.0 -0.026 73.0 noncon
hsa-miR-5089-3p 2012-2019 -0.296 94.0 -0.07 70.0 noncon
hsa-miR-4505 633-640 -0.293 95.0 -0.069 71.0 noncon
hsa-miR-6744-5p 1997-2003 -0.287 95.0 -0.068 77.0 noncon
hsa-miR-326 1249-1256 -0.287 96.0 -0.068 76.0 noncon
hsa-miR-92a-1-5p 81-87 -0.285 90.0 -0.181 81.0 noncon
hsa-miR-6782-5p 503-509 -0.279 91.0 -0.177 82.0 noncon
hsa-miR-544b 1023-1030 -0.278 97.0 -0.066 77.0 noncon
hsa-miR-6768-3p 47-53 -0.272 96.0 -0.272 98.0 noncon
hsa-miR-4519 994-1001 -0.271 95.0 -0.065 76.0 noncon
hsa-miR-1909-5p 473-479 -0.266 92.0 -0.169 90.0 noncon
hsa-miR-330-5p 1249-1256 -0.266 96.0 -0.064 75.0 noncon
hsa-miR-3670 2867-2874 -0.265 93.0 -0.057 59.0 noncon
hsa-miR-5693 3035-3042 -0.263 98.0 -0.056 87.0 noncon
hsa-miR-4638-3p 4008-4015 -0.262 93.0 -0.023 48.0 noncon
hsa-miR-6849-3p 302-309 -0.261 97.0 -0.166 94.0 noncon
hsa-miR-4654 1191-1197 -0.257 95.0 -0.062 69.0 noncon
hsa-miR-6741-5p 1481-1488 -0.256 97.0 -0.061 84.0 noncon
hsa-miR-6743-5p 799-806 -0.252 92.0 -0.06 57.0 noncon
hsa-miR-642a-3p 2936-2943 -0.251 96.0 -0.054 76.0 noncon
hsa-miR-642b-3p 2936-2943 -0.251 96.0 -0.054 77.0 noncon
hsa-miR-4688 799-806 -0.25 90.0 -0.06 56.0 noncon