GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
B4GALT7



General Information
Gene Symbol:   
B4GALT7
Protein name:   
Beta-1,4-galactosyltransferase 7
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT7
E.C. No:   
2.4.1.133
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• β4GalT7 transfers galactose from UDP-Gal to Xylβ1-Ser and is involved in the biosynthesis of the linkage between core proteins and glycosaminoglycans.

Related Pathway
KEGG ORTHOLOGY:   
K00733
KEGG Pathway:   
ko00532  ko00534  ko01100 
Reactome:   
R-HSA-1971475
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9UBV7 
NCBI GeneID:   
11285
GlyMap GeneID:   
11285
DNA aRefSeq:   
NM_007255.2 
Protein RefSeq:   
NP_009186.1 
BRENDA:   
Kinetic info.
OMIM number:   
604327
GeneCards database:   
B4GALT7
Enzyme Specificity
Glycan Type:  
     GAG
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Xyl(b1-?)Ser
Product:  
     Gal(b1-4)Xyl(b1-?)Ser
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    5.75e-04    (pmol/cell • hr)       KM:    1.50e+08    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-7110-5p 338-345 -0.598 98.0 -0.594 98.0 noncon
hsa-miR-6885-5p 4371-4378 -0.593 97.0 -0.036 36.0 noncon
hsa-miR-6770-3p 142-149 -0.559 98.0 -0.559 98.0 noncon
hsa-miR-6842-5p 338-345 -0.558 98.0 -0.554 98.0 noncon
hsa-miR-328-5p 4371-4378 -0.531 97.0 -0.032 43.0 noncon
hsa-miR-3151-5p 462-469 -0.527 99.0 -0.523 99.0 noncon
hsa-miR-6735-3p 31-38 -0.522 99.0 -0.522 99.0 noncon
hsa-miR-6752-5p 338-345 -0.498 98.0 -0.494 98.0 noncon
hsa-miR-6876-3p 111-118 -0.49 98.0 -0.49 99.0 noncon
hsa-miR-626 111-118 -0.482 98.0 -0.482 98.0 noncon
hsa-miR-6812-3p 3838-3845 -0.464 97.0 -0.029 38.0 noncon
hsa-miR-338-3p 566-573 -0.462 99.0 -0.262 98.0 con
hsa-miR-1180-3p 511-517 -0.424 94.0 -0.421 95.0 noncon
hsa-miR-3128 531-538 -0.419 99.0 -0.416 99.0 noncon
hsa-miR-4746-3p 485-491 -0.407 96.0 -0.404 97.0 noncon
hsa-miR-3934-3p 1293-1300 -0.379 98.0 -0.025 53.0 noncon
hsa-miR-637 3390-3397 -0.36 97.0 -0.023 51.0 noncon
hsa-miR-196a-3p 529-536 -0.359 97.0 -0.356 98.0 noncon
hsa-miR-339-5p 2558-2565 -0.349 96.0 -0.023 61.0 noncon
hsa-miR-210-5p 2503-2510 -0.347 97.0 -0.022 46.0 noncon
hsa-miR-4747-3p 521-527 -0.346 98.0 -0.344 99.0 noncon
hsa-miR-3176 640-647 -0.344 98.0 -0.023 63.0 noncon
hsa-miR-5586-5p 568-574 -0.342 97.0 -0.197 93.0 noncon
hsa-miR-7109-5p 4372-4379 -0.338 95.0 -0.022 46.0 noncon
hsa-miR-3665 1753-1760 -0.336 96.0 -0.022 45.0 noncon
hsa-miR-4763-5p 948-955 -0.336 91.0 -0.022 46.0 noncon
hsa-miR-1266-3p 319-326 -0.336 97.0 -0.336 98.0 noncon
hsa-miR-6817-3p 214-221 -0.334 98.0 -0.334 99.0 noncon
hsa-miR-5580-5p 480-487 -0.333 95.0 -0.331 96.0 noncon
hsa-miR-5581-5p 2287-2294 -0.33 94.0 -0.021 49.0 noncon
hsa-miR-1199-3p 140-146 -0.33 93.0 -0.33 94.0 noncon
hsa-miR-4671-3p 3984-3991 -0.33 93.0 -0.021 33.0 noncon
hsa-miR-4297 2287-2294 -0.328 95.0 -0.021 54.0 noncon
hsa-miR-6751-5p 339-345 -0.319 96.0 -0.317 97.0 noncon
hsa-miR-3922-3p 640-647 -0.318 98.0 -0.022 61.0 noncon
hsa-miR-662 174-180 -0.317 93.0 -0.317 95.0 noncon
hsa-miR-5588-3p 4250-4257 -0.313 97.0 -0.02 42.0 noncon
hsa-miR-3972 715-722 -0.313 96.0 -0.021 62.0 noncon
hsa-miR-196a-3p 502-509 -0.307 95.0 -0.305 96.0 noncon
hsa-miR-4792 262-268 -0.299 95.0 -0.299 96.0 noncon
hsa-miR-4472 340-346 -0.294 96.0 -0.292 97.0 noncon
hsa-miR-4447 340-346 -0.294 96.0 -0.292 97.0 noncon
hsa-miR-4790-5p 1786-1793 -0.293 91.0 -0.019 37.0 noncon
hsa-miR-494-5p 325-331 -0.292 93.0 -0.292 95.0 noncon
hsa-miR-134-3p 464-471 -0.291 96.0 -0.289 97.0 noncon
hsa-miR-4512 3880-3887 -0.29 96.0 -0.019 44.0 noncon
hsa-miR-4749-3p 687-694 -0.29 93.0 -0.02 51.0 noncon
hsa-miR-6801-5p 273-279 -0.289 96.0 -0.289 97.0 noncon
hsa-miR-4438 20-27 -0.289 98.0 -0.289 98.0 noncon
hsa-miR-3907 1296-1303 -0.287 93.0 -0.019 45.0 noncon
hsa-miR-6889-3p 4107-4113 -0.287 95.0 -0.019 57.0 noncon
hsa-miR-4433a-5p 3940-3947 -0.287 95.0 -0.019 57.0 noncon
hsa-miR-214-5p 2302-2309 -0.285 96.0 -0.019 69.0 noncon
hsa-miR-3126-3p 533-539 -0.283 95.0 -0.281 97.0 noncon
hsa-miR-1915-5p 718-725 -0.282 92.0 -0.019 49.0 noncon
hsa-miR-5591-5p 1688-1695 -0.275 92.0 -0.018 38.0 noncon
hsa-miR-5007-3p 4453-4460 -0.272 97.0 -0.018 57.0 noncon
hsa-miR-874-5p 392-398 -0.271 91.0 -0.269 93.0 noncon
hsa-miR-323b-5p 325-331 -0.27 91.0 -0.27 94.0 noncon
hsa-miR-4300 1688-1695 -0.267 92.0 -0.018 39.0 noncon
hsa-miR-1296-3p 341-347 -0.264 96.0 -0.262 97.0 noncon
hsa-miR-6726-5p 1688-1695 -0.264 91.0 -0.018 37.0 noncon
hsa-miR-510-5p 4240-4247 -0.264 96.0 -0.018 55.0 noncon
hsa-miR-6756-3p 1000-1007 -0.261 91.0 -0.018 52.0 noncon
hsa-miR-6803-5p 339-345 -0.261 92.0 -0.259 94.0 noncon
hsa-miR-339-5p 4304-4310 -0.261 92.0 -0.017 57.0 noncon
hsa-miR-6778-3p 1149-1156 -0.261 94.0 -0.018 56.0 noncon
hsa-miR-410-5p 325-331 -0.259 91.0 -0.259 93.0 noncon
hsa-miR-503-5p 191-197 -0.254 97.0 -0.254 97.0 noncon
hsa-miR-1199-5p 48-54 -0.253 95.0 -0.253 96.0 noncon
hsa-miR-19a-3p 4447-4454 -0.253 90.0 -0.017 37.0 noncon
hsa-miR-19b-3p 4447-4454 -0.253 90.0 -0.017 37.0 noncon
hsa-miR-4721 3527-3534 -0.25 90.0 -0.017 34.0 noncon