GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
DSE



General Information
Gene Symbol:   
DSE
Protein name:   
Dermatan-sulfate epimerase
Enzyme Class:   
Epimerase
CAZy Family:   
E.C. No:   
5.1.3.19
Organs:   
Reaction (SNFG):   
→
Reaction (IUBMB):   
No specified reaction.
About

• DS is derived from CS by the epimerization of GlcA to IdoA. By definition, a single iduronic acid is sufficient to name the chain DS
• Dermatan sulfate epimerase 1 and 2 epimerize glucuronic acid to iduronic acid in DS
• After epimerization of the chain, the C2 hydroxyl group of GlcA/IdoA and the C4 and/or C6 hydroxyl group of GalNAc can be sulfated, giving rise to seven different disaccharide structures
• Disregulation of the epimerase activity results in the propagation of various inflammatory and oncological disorders

Related Pathway
KEGG ORTHOLOGY:   
K01794
KEGG Pathway:   
ko00532  ko01100 
Reactome:   
R-HSA-2022923
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9UL01 
NCBI GeneID:   
29940
GlyMap GeneID:   
29940
DNA aRefSeq:   
NM_001080976.2 
Protein RefSeq:   
NP_001074445.1 
BRENDA:   
Kinetic info.
OMIM number:   
605942
GeneCards database:   
DSE
Enzyme Specificity
Glycan Type:  
     GAG
Compartment:  
     
Substrate:  
     ...GlcA(b1-3)
Product:  
     ...IdoA(a1-3)
Constraints:  
     !@GlcA(b1-3)Gal(b1-3)Gal(b1-4)Xyl(b1-r)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 10 8 6 4 2 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data