GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGDH



General Information
Gene Symbol:   
UGDH
Protein name:   
UDP-glucose 6-dehydrogenase
Enzyme Class:   
CAZy Family:   
E.C. No:   
1.1.1.22
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

UDP-Glc → UDP-GlcA
Reaction (IUBMB):   
No specified reaction.
About

• UDP-Glucose-6-dehydrogenase catalyzes the reaction to form UDP-glucuronic acid from UDP-glucose. Provides a pathway for UDP-GlcA to be synthesized for GAG synthesis in sugar nucleotide pathways.
• UGDH polymorphisms cause heart valve deformities during development in rare instances.
• Osteoarthritis is perpetuated by the lack of UGDH which provides additional GlcA for GAG regeneration in the synovial fluid.
• UGDH activity can be enhanced in some tumors. It causes an increase in hyaluronan synthesis, which can cause an increase in metastatic potential.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-173599
Related Database
Organism:   
Homo sapiens
Uniprot:   
O60701 
NCBI GeneID:   
7358
GlyMap GeneID:   
7358
DNA aRefSeq:   
NM_001184700.1 
Protein RefSeq:   
NP_001171629.1 
BRENDA:   
Kinetic info.
OMIM number:   
603370
GeneCards database:   
UGDH
Enzyme Specificity
Glycan Type:  
     GAG
Compartment:  
     
Substrate:  
     UDP-Glc
Product:  
     UDP-GlcA
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3117-5p 568-575 -0.644 99.0 -0.525 99.0 noncon
hsa-miR-8082 1374-1381 -0.6 99.0 -0.042 60.0 noncon
hsa-miR-4534 1374-1381 -0.54 99.0 -0.039 70.0 noncon
hsa-miR-6812-5p 847-854 -0.486 98.0 -0.072 68.0 noncon
hsa-miR-6891-3p 1324-1331 -0.482 99.0 -0.035 69.0 noncon
hsa-miR-4537 163-170 -0.458 96.0 -0.378 95.0 noncon
hsa-miR-6072 1324-1331 -0.453 99.0 -0.033 68.0 noncon
hsa-miR-6819-5p 847-854 -0.452 98.0 -0.068 66.0 noncon
hsa-miR-6737-5p 847-854 -0.452 98.0 -0.068 67.0 noncon
hsa-miR-4719 15-22 -0.447 99.0 -0.447 99.0 noncon
hsa-miR-5585-5p 42-49 -0.445 99.0 -0.445 99.0 noncon
hsa-miR-4777-5p 488-495 -0.443 99.0 -0.366 99.0 noncon
hsa-miR-4529-3p 957-964 -0.439 97.0 -0.066 66.0 noncon
hsa-miR-490-5p 720-727 -0.438 99.0 -0.152 92.0 noncon
hsa-miR-610 815-822 -0.424 99.0 -0.146 84.0 noncon
hsa-miR-3689a-5p 643-650 -0.42 98.0 -0.262 96.0 noncon
hsa-miR-3689b-5p 643-650 -0.42 98.0 -0.262 96.0 noncon
hsa-miR-3689e 643-650 -0.42 98.0 -0.262 96.0 noncon
hsa-miR-3175 912-919 -0.412 98.0 -0.063 58.0 noncon
hsa-miR-3689f 643-650 -0.412 98.0 -0.257 96.0 noncon
hsa-miR-921 936-943 -0.408 98.0 -0.062 71.0 noncon
hsa-miR-642a-3p 799-806 -0.401 98.0 -0.139 92.0 noncon
hsa-miR-5190 803-810 -0.397 99.0 -0.137 93.0 noncon
hsa-miR-642b-3p 799-806 -0.393 98.0 -0.136 92.0 noncon
hsa-miR-4502 437-444 -0.391 99.0 -0.324 99.0 noncon
hsa-miR-769-5p 1268-1275 -0.384 98.0 -0.033 67.0 noncon
hsa-miR-6734-3p 658-665 -0.374 98.0 -0.235 94.0 noncon
hsa-miR-610 522-529 -0.363 98.0 -0.301 97.0 noncon
hsa-miR-4469 1306-1313 -0.361 99.0 -0.027 78.0 noncon
hsa-miR-452-3p 1346-1353 -0.348 98.0 -0.026 65.0 noncon
hsa-miR-8066 646-653 -0.346 99.0 -0.218 97.0 noncon
hsa-miR-644a 632-638 -0.345 96.0 -0.218 92.0 noncon
hsa-miR-624-5p 40-46 -0.342 95.0 -0.342 97.0 noncon
hsa-miR-142-5p 612-619 -0.313 99.0 -0.198 98.0 noncon
hsa-miR-4475 1214-1220 -0.31 97.0 -0.033 73.0 noncon
hsa-miR-7108-5p 631-637 -0.309 98.0 -0.196 94.0 noncon
hsa-miR-6832-5p 1340-1347 -0.309 95.0 -0.024 45.0 noncon
hsa-miR-380-3p 1355-1362 -0.309 99.0 -0.024 75.0 noncon
hsa-miR-8055 818-825 -0.308 99.0 -0.048 88.0 noncon
hsa-miR-4726-5p 389-396 -0.307 92.0 -0.256 91.0 noncon
hsa-miR-411-3p 1080-1087 -0.305 99.0 -0.048 88.0 noncon
hsa-miR-379-3p 1080-1087 -0.305 99.0 -0.048 88.0 noncon
hsa-miR-5572 848-855 -0.304 97.0 -0.048 72.0 noncon
hsa-miR-3150a-3p 913-919 -0.298 95.0 -0.047 64.0 noncon
hsa-miR-4640-5p 389-396 -0.297 92.0 -0.248 90.0 noncon
hsa-miR-7851-3p 1265-1271 -0.297 95.0 -0.026 52.0 noncon
hsa-miR-4717-3p 295-302 -0.297 97.0 -0.248 97.0 noncon
hsa-miR-181a-2-3p 1165-1171 -0.297 98.0 -0.047 73.0 noncon
hsa-miR-29b-2-5p 1036-1043 -0.297 98.0 -0.047 81.0 noncon
hsa-miR-7845-5p 1213-1219 -0.296 95.0 -0.032 47.0 noncon
hsa-miR-3119 962-969 -0.295 96.0 -0.046 70.0 noncon
hsa-miR-514a-3p 570-576 -0.295 97.0 -0.246 97.0 noncon
hsa-miR-1285-3p 134-140 -0.295 97.0 -0.246 97.0 noncon
hsa-miR-3614-5p 89-95 -0.294 97.0 -0.245 97.0 noncon
hsa-miR-5590-3p 612-619 -0.294 99.0 -0.187 98.0 noncon
hsa-miR-204-5p 655-662 -0.289 96.0 -0.184 93.0 noncon
hsa-miR-5089-3p 897-903 -0.287 94.0 -0.045 59.0 noncon
hsa-miR-4495 500-507 -0.285 99.0 -0.238 98.0 noncon
hsa-miR-4687-3p 741-747 -0.285 95.0 -0.101 83.0 noncon
hsa-miR-3661 1266-1272 -0.282 93.0 -0.025 48.0 noncon
hsa-miR-433-3p 880-887 -0.282 97.0 -0.045 76.0 noncon
hsa-miR-211-5p 655-662 -0.281 96.0 -0.179 93.0 noncon
hsa-miR-1322 1090-1096 -0.28 98.0 -0.044 85.0 noncon
hsa-miR-4457 327-334 -0.28 97.0 -0.234 96.0 noncon
hsa-miR-3166 1124-1130 -0.276 92.0 -0.044 53.0 noncon
hsa-miR-514b-3p 570-576 -0.273 96.0 -0.228 96.0 noncon
hsa-miR-7851-3p 186-192 -0.272 93.0 -0.227 93.0 noncon
hsa-miR-631 1266-1272 -0.272 92.0 -0.024 45.0 noncon
hsa-miR-8085 911-917 -0.271 93.0 -0.043 59.0 noncon
hsa-miR-6731-5p 911-917 -0.271 93.0 -0.043 60.0 noncon
hsa-miR-4284 299-306 -0.271 98.0 -0.226 98.0 noncon
hsa-miR-4755-3p 253-259 -0.269 93.0 -0.225 93.0 noncon
hsa-miR-4531 1372-1378 -0.268 96.0 -0.021 49.0 noncon
hsa-miR-339-5p 283-289 -0.266 93.0 -0.222 92.0 noncon
hsa-miR-6763-5p 913-919 -0.265 93.0 -0.042 61.0 noncon
hsa-miR-548ap-3p 559-566 -0.264 98.0 -0.221 98.0 noncon
hsa-miR-548aa 559-566 -0.264 98.0 -0.221 98.0 noncon
hsa-miR-548t-3p 559-566 -0.264 98.0 -0.221 98.0 noncon
hsa-miR-3614-5p 401-407 -0.259 96.0 -0.216 96.0 noncon
hsa-miR-4708-5p 1337-1343 -0.256 96.0 -0.02 66.0 noncon
hsa-miR-6779-5p 349-356 -0.255 91.0 -0.213 92.0 noncon
hsa-miR-4768-3p 319-326 -0.254 98.0 -0.212 97.0 noncon
hsa-miR-548a-5p 610-617 -0.252 99.0 -0.161 97.0 noncon
hsa-miR-548ar-5p 610-617 -0.252 99.0 -0.161 97.0 noncon
hsa-miR-6747-5p 847-853 -0.251 93.0 -0.04 51.0 noncon
hsa-miR-1255a 1272-1278 -0.25 91.0 -0.021 45.0 noncon