GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PIGH



General Information
Gene Symbol:   
PIGH
Protein name:   
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
2.4.1.198
Organs:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

• GPI-GnT: GlcNAcT activity that is necessary to form the core glycan structure on GPI-anchored proteins
• Subunit PIGA has catalytic activity, while PIGC, PIGH, PIGQ, PIGP and PIGY have other essential functions
• DPM2 is regulatory and it functions to enhance GPI-GnT activity

Related Pathway
KEGG ORTHOLOGY:   
K03858
KEGG Pathway:   
ko00563  ko01100 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q14442 
NCBI GeneID:   
5283
GlyMap GeneID:   
5283
DNA aRefSeq:   
NM_004569.3 
Protein RefSeq:   
NP_004560.1 
BRENDA:   
Kinetic info.
OMIM number:   
600154
GeneCards database:   
PIGH
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     No reaction
Product:  
     
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-628-5p 267-274 -0.656 99.0 -0.656 99.0 noncon
hsa-miR-7-5p 27-34 -0.614 99.0 -0.614 99.0 con
hsa-miR-3176 692-699 -0.589 99.0 -0.265 97.0 noncon
hsa-miR-3922-3p 692-699 -0.579 99.0 -0.261 97.0 noncon
hsa-miR-6887-3p 222-229 -0.568 99.0 -0.568 99.0 noncon
hsa-miR-6871-3p 1332-1339 -0.563 99.0 -0.007 43.0 noncon
hsa-miR-8077 632-639 -0.547 99.0 -0.248 98.0 noncon
hsa-miR-6802-3p 1100-1107 -0.536 99.0 -0.006 42.0 noncon
hsa-miR-892a 246-253 -0.533 99.0 -0.533 99.0 noncon
hsa-miR-6822-3p 130-137 -0.533 99.0 -0.533 99.0 noncon
hsa-miR-203b-3p 653-660 -0.532 99.0 -0.242 98.0 noncon
hsa-miR-4708-3p 1140-1147 -0.492 99.0 -0.006 37.0 noncon
hsa-miR-636 608-615 -0.486 99.0 -0.223 95.0 noncon
hsa-miR-6870-3p 680-687 -0.472 99.0 -0.217 96.0 noncon
hsa-miR-4753-5p 964-971 -0.471 99.0 -0.006 29.0 noncon
hsa-miR-5571-3p 100-107 -0.469 99.0 -0.469 99.0 noncon
hsa-miR-2682-3p 1165-1172 -0.467 99.0 -0.006 38.0 noncon
hsa-miR-135b-5p 50-57 -0.46 98.0 -0.46 99.0 con
hsa-miR-135a-5p 50-57 -0.46 98.0 -0.46 99.0 con
hsa-miR-8069 80-87 -0.458 99.0 -0.458 99.0 noncon
hsa-miR-223-3p 346-353 -0.446 98.0 -0.424 98.0 noncon
hsa-miR-3120-5p 696-703 -0.443 98.0 -0.205 95.0 noncon
hsa-miR-3679-3p 850-857 -0.439 97.0 -0.005 45.0 noncon
hsa-miR-6862-3p 1218-1225 -0.428 98.0 -0.005 46.0 noncon
hsa-miR-6781-3p 1165-1172 -0.422 99.0 -0.005 37.0 noncon
hsa-miR-1289 914-920 -0.418 97.0 -0.005 34.0 noncon
hsa-miR-2116-3p 34-41 -0.418 99.0 -0.418 99.0 noncon
hsa-miR-3169 96-103 -0.416 99.0 -0.416 99.0 noncon
hsa-miR-6784-3p 1218-1225 -0.415 98.0 -0.005 44.0 noncon
hsa-miR-513c-5p 362-369 -0.412 99.0 -0.392 99.0 noncon
hsa-miR-6836-5p 1019-1026 -0.408 98.0 -0.005 36.0 noncon
hsa-miR-6132 1019-1026 -0.405 97.0 -0.005 33.0 noncon
hsa-miR-6888-3p 697-704 -0.396 98.0 -0.185 94.0 noncon
hsa-miR-16-2-3p 761-768 -0.395 99.0 -0.182 97.0 noncon
hsa-miR-6844 743-750 -0.391 99.0 -0.18 95.0 noncon
hsa-miR-6715b-5p 478-484 -0.391 99.0 -0.372 99.0 noncon
hsa-miR-19b-1-5p 332-339 -0.39 99.0 -0.371 99.0 noncon
hsa-miR-514b-5p 362-369 -0.388 99.0 -0.37 99.0 noncon
hsa-miR-6738-3p 1169-1176 -0.385 98.0 -0.005 44.0 noncon
hsa-miR-563 469-475 -0.382 97.0 -0.364 98.0 noncon
hsa-miR-19b-2-5p 332-339 -0.382 99.0 -0.364 99.0 noncon
hsa-miR-380-5p 469-475 -0.381 97.0 -0.363 97.0 noncon
hsa-miR-195-3p 761-768 -0.379 99.0 -0.175 97.0 noncon
hsa-miR-19a-5p 332-339 -0.374 99.0 -0.356 99.0 noncon
hsa-miR-4712-5p 427-433 -0.371 98.0 -0.354 98.0 noncon
hsa-miR-5001-3p 1168-1175 -0.368 98.0 -0.004 35.0 noncon
hsa-miR-4766-3p 290-297 -0.362 98.0 -0.345 98.0 noncon
hsa-miR-374b-3p 1340-1347 -0.361 98.0 -0.004 41.0 noncon
hsa-miR-770-5p 427-433 -0.36 98.0 -0.343 98.0 noncon
hsa-miR-146b-3p 493-499 -0.353 98.0 -0.336 98.0 noncon
hsa-miR-1248 675-682 -0.35 98.0 -0.165 93.0 noncon
hsa-miR-1295b-5p 939-946 -0.35 98.0 -0.004 34.0 noncon
hsa-miR-646 560-566 -0.346 98.0 -0.163 93.0 noncon
hsa-miR-208b-5p 659-666 -0.346 99.0 -0.163 95.0 noncon
hsa-miR-1912 939-946 -0.345 98.0 -0.004 30.0 noncon
hsa-miR-384 1396-1403 -0.344 98.0 -0.004 45.0 noncon
hsa-miR-4731-3p 393-400 -0.343 99.0 -0.327 99.0 noncon
hsa-miR-4743-3p 698-705 -0.343 99.0 -0.162 95.0 noncon
hsa-miR-3936 389-395 -0.342 98.0 -0.326 98.0 noncon
hsa-miR-6793-3p 1309-1315 -0.342 98.0 -0.004 49.0 noncon
hsa-miR-6779-3p 494-500 -0.331 98.0 -0.316 98.0 noncon
hsa-miR-4801 393-400 -0.33 99.0 -0.315 99.0 noncon
hsa-miR-3140-5p 1033-1040 -0.329 98.0 -0.004 41.0 noncon
hsa-miR-6769b-3p 1223-1230 -0.329 97.0 -0.004 40.0 noncon
hsa-miR-218-1-3p 104-110 -0.326 96.0 -0.326 97.0 noncon
hsa-miR-4255 276-282 -0.323 98.0 -0.323 98.0 noncon
hsa-miR-3977 328-335 -0.321 98.0 -0.306 99.0 noncon
hsa-miR-6857-5p 1087-1094 -0.32 98.0 -0.004 31.0 noncon
hsa-miR-194-5p 627-633 -0.318 98.0 -0.151 91.0 noncon
hsa-miR-4457 392-398 -0.316 98.0 -0.301 98.0 noncon
hsa-miR-3158-3p 417-423 -0.314 97.0 -0.299 97.0 noncon
hsa-miR-602 174-180 -0.308 95.0 -0.308 96.0 noncon
hsa-miR-218-5p 609-615 -0.307 95.0 -0.146 87.0 con
hsa-miR-216b-3p 1108-1115 -0.306 97.0 -0.004 42.0 noncon
hsa-miR-4723-3p 1223-1230 -0.305 96.0 -0.004 39.0 noncon
hsa-miR-29b-1-5p 992-999 -0.302 97.0 -0.004 44.0 noncon
hsa-miR-6875-3p 440-447 -0.297 97.0 -0.283 98.0 noncon
hsa-miR-4693-5p 247-253 -0.297 97.0 -0.297 97.0 noncon
hsa-miR-5588-3p 727-733 -0.297 96.0 -0.141 86.0 noncon
hsa-miR-4269 478-484 -0.295 98.0 -0.281 99.0 noncon
hsa-miR-592 244-250 -0.292 97.0 -0.292 97.0 noncon
hsa-miR-6802-3p 1217-1223 -0.29 93.0 -0.004 38.0 noncon
hsa-miR-5572 865-872 -0.289 97.0 -0.004 36.0 noncon
hsa-miR-562 663-669 -0.289 97.0 -0.138 92.0 noncon
hsa-miR-4279 1226-1233 -0.288 97.0 -0.004 49.0 noncon
hsa-miR-140-3p.2 1043-1050 -0.285 97.0 -0.004 42.0 noncon
hsa-miR-4682 1407-1413 -0.285 97.0 -0.004 42.0 noncon
hsa-miR-519d-3p 1361-1368 -0.283 97.0 -0.004 59.0 con
hsa-miR-93-5p 1361-1368 -0.283 97.0 -0.004 60.0 con
hsa-miR-20b-5p 1361-1368 -0.283 97.0 -0.004 59.0 con
hsa-miR-17-5p 1361-1368 -0.283 97.0 -0.004 59.0 con
hsa-miR-106a-5p 1361-1368 -0.28 97.0 -0.004 57.0 con
hsa-let-7f-2-3p 795-802 -0.28 98.0 -0.004 51.0 noncon
hsa-miR-3136-5p 595-601 -0.279 96.0 -0.133 87.0 noncon
hsa-miR-6864-5p 420-426 -0.277 95.0 -0.264 96.0 noncon
hsa-miR-1185-1-3p 795-802 -0.277 98.0 -0.004 48.0 noncon
hsa-miR-1185-2-3p 795-802 -0.277 98.0 -0.004 48.0 noncon
hsa-miR-3922-3p 16-22 -0.276 96.0 -0.276 97.0 noncon
hsa-miR-3190-5p 693-699 -0.275 97.0 -0.131 88.0 noncon
hsa-miR-486-5p 491-497 -0.273 97.0 -0.261 97.0 noncon
hsa-miR-6793-3p 831-838 -0.272 97.0 -0.004 48.0 noncon
hsa-miR-369-3p 178-185 -0.272 99.0 -0.272 99.0 noncon
hsa-miR-4704-3p 146-152 -0.269 95.0 -0.269 96.0 noncon
hsa-miR-208a-5p 659-666 -0.268 99.0 -0.128 97.0 noncon
hsa-miR-545-5p 507-513 -0.266 97.0 -0.254 98.0 noncon
hsa-miR-4728-3p 634-640 -0.264 97.0 -0.126 89.0 noncon
hsa-miR-1537-5p 1236-1243 -0.264 90.0 -0.003 18.0 noncon
hsa-miR-3140-3p 658-664 -0.263 98.0 -0.126 91.0 noncon
hsa-miR-20a-5p 1361-1368 -0.262 97.0 -0.003 58.0 con
hsa-miR-106b-5p 1361-1368 -0.262 97.0 -0.003 58.0 con
hsa-miR-6830-5p 191-197 -0.26 97.0 -0.26 97.0 noncon
hsa-miR-4682 160-166 -0.259 96.0 -0.259 97.0 noncon
hsa-miR-182-5p 670-676 -0.259 92.0 -0.124 80.0 noncon
hsa-miR-6885-3p 756-762 -0.257 97.0 -0.121 92.0 noncon
hsa-miR-140-3p.1 1042-1048 -0.256 96.0 -0.003 42.0 noncon
hsa-miR-3176 16-22 -0.255 96.0 -0.255 97.0 noncon
hsa-miR-892a 537-543 -0.254 96.0 -0.124 90.0 noncon
hsa-miR-6892-3p 842-848 -0.253 92.0 -0.003 41.0 noncon