GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PIGQ



General Information
Gene Symbol:   
PIGQ
Protein name:   
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
2.4.1.198
Organs:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

• GPI-GnT: GlcNAcT activity that is necessary to form the core glycan structure on GPI-anchored proteins
• Subunit PIGA has catalytic activity, while PIGC, PIGH, PIGQ, PIGP and PIGY have other essential functions
• DPM2 is regulatory and it functions to enhance GPI-GnT activity

Related Pathway
KEGG ORTHOLOGY:   
K03860
KEGG Pathway:   
ko00563  ko01100 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9BRB3 
NCBI GeneID:   
9091
GlyMap GeneID:   
9091
DNA aRefSeq:   
NM_004204.3 
Protein RefSeq:   
NP_004195.2 
BRENDA:   
Kinetic info.
OMIM number:   
605754
GeneCards database:   
PIGQ
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     No reaction
Product:  
     
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6763-3p 1025-1032 -0.497 97.0 -0.48 97.0 noncon
hsa-miR-6721-5p 1058-1064 -0.445 98.0 -0.43 98.0 noncon
hsa-miR-4670-5p 587-593 -0.418 92.0 -0.418 93.0 noncon
hsa-miR-184 337-344 -0.387 94.0 -0.387 95.0 noncon
hsa-miR-661 447-454 -0.38 98.0 -0.38 99.0 noncon
hsa-miR-486-3p 299-306 -0.369 94.0 -0.369 95.0 noncon
hsa-miR-5090 1060-1066 -0.365 93.0 -0.353 94.0 noncon
hsa-miR-6775-5p 1060-1066 -0.346 91.0 -0.335 92.0 noncon
hsa-miR-6129 463-470 -0.325 96.0 -0.325 97.0 noncon
hsa-miR-492 324-331 -0.318 94.0 -0.318 96.0 noncon
hsa-miR-6127 463-470 -0.317 95.0 -0.317 96.0 noncon
hsa-miR-6133 463-470 -0.317 96.0 -0.317 96.0 noncon
hsa-miR-4419a 463-470 -0.309 95.0 -0.309 96.0 noncon
hsa-miR-4510 463-470 -0.301 95.0 -0.301 96.0 noncon
hsa-miR-6130 463-470 -0.301 95.0 -0.301 96.0 noncon
hsa-miR-4292 757-764 -0.299 96.0 -0.289 97.0 noncon
hsa-miR-7113-5p 577-584 -0.298 97.0 -0.298 97.0 noncon
hsa-miR-6729-3p 942-949 -0.297 95.0 -0.288 96.0 noncon
hsa-miR-203a-5p 549-556 -0.294 95.0 -0.294 96.0 noncon
hsa-miR-6791-5p 757-764 -0.291 95.0 -0.282 96.0 noncon
hsa-miR-7515 742-749 -0.291 96.0 -0.282 97.0 noncon
hsa-miR-4270 543-550 -0.286 97.0 -0.286 97.0 noncon
hsa-miR-6754-5p 543-550 -0.283 97.0 -0.283 97.0 noncon
hsa-miR-4441 543-550 -0.28 97.0 -0.28 97.0 noncon
hsa-miR-8071 340-347 -0.28 95.0 -0.28 96.0 noncon
hsa-miR-8073 426-433 -0.277 97.0 -0.277 97.0 noncon
hsa-miR-4665-3p 844-850 -0.274 91.0 -0.265 93.0 noncon
hsa-miR-8052 443-450 -0.264 92.0 -0.264 94.0 noncon
hsa-miR-221-5p 426-433 -0.261 96.0 -0.261 97.0 noncon
hsa-miR-4755-3p 16-23 -0.251 92.0 -0.251 95.0 noncon
hsa-miR-7974 36-43 -0.251 90.0 -0.251 92.0 noncon