GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PIGV



General Information
Gene Symbol:   
PIGV
Protein name:   
GPI mannosyltransferase 2
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT76
E.C. No:   
2.4.1.*
Organs:   
Reaction (SNFG):   

Man(a1-4)GlcN(a1-6)(ancyl)PI → Man(a1-6)Man(a1-4)GlcN(a1-6)(ancyl)PI
Reaction (IUBMB):   
No specified reaction.
About

• This transfers the second Man from Dol-P-Man during GPI-anchored protein biosynthesis

Related Pathway
KEGG ORTHOLOGY:   
K07542
KEGG Pathway:   
ko00563  ko01100 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9NUD9 
NCBI GeneID:   
55650
GlyMap GeneID:   
55650
DNA aRefSeq:   
NM_001202554.1 
Protein RefSeq:   
NP_001189483.1 
BRENDA:   
Kinetic info.
OMIM number:   
610274
GeneCards database:   
PIGV
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     Man(a1-4)GlcN(a1-6)(ancyl)PI
Product:  
     Man(a1-6)Man(a1-4)GlcN(a1-6)(ancyl)PI
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data