GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PIGW



General Information
Gene Symbol:   
PIGW
Protein name:   
Phosphatidylinositol-glycan biosynthesis class W protein
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.3.*.*
Organs:   
Reaction (SNFG):   

GlcN(a1-6)PI → GlcN(a1-6)(ancyl)PI
Reaction (IUBMB):   
No specified reaction.
About

• This is a GlcN-PI acyltransferase that helps synthesize the GPI glycan core

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q7Z7B1 
NCBI GeneID:   
284098
GlyMap GeneID:   
284098
DNA aRefSeq:   
NM_001346754.1 
Protein RefSeq:   
NP_001333683.1 
BRENDA:   
Kinetic info.
OMIM number:   
610275
GeneCards database:   
PIGW
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     GlcN(a1-6)PI
Product:  
     GlcN(a1-6)(ancyl)PI
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 6 4 2 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data