GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
PIGY



General Information
Gene Symbol:   
PIGY
Protein name:   
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

• GPI-GnT: GlcNAcT activity that is necessary to form the core glycan structure on GPI-anchored proteins
• Subunit PIGA has catalytic activity, while PIGC, PIGH, PIGQ, PIGP and PIGY have other essential functions
• DPM2 is regulatory and it functions to enhance GPI-GnT activity

Related Pathway
KEGG ORTHOLOGY:   
K11001
KEGG Pathway:   
ko00563  ko01100 
Reactome:   
R-HSA-162710
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q3MUY2 
NCBI GeneID:   
84992
GlyMap GeneID:   
84992
DNA aRefSeq:   
NM_001042616.2 
Protein RefSeq:   
NP_001036081.1 
BRENDA:   
Kinetic info.
OMIM number:   
610662
GeneCards database:   
PIGY
Enzyme Specificity
Glycan Type:  
     GPI
Compartment:  
     ER
Substrate:  
     No reaction
Product:  
     
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 60 50 40 30 20 10 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data