GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
B4GALT6



General Information
Gene Symbol:   
B4GALT6
Protein name:   
Beta-1,4-galactosyltransferase 6
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT7
E.C. No:   
2.4.1.274
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• This is a lactosylceramide synthase. It forms the LacCer entity.
• LacCer is the starting point in the biosynthesis of many different glycolipids, including all gangliosides

Related Pathway
KEGG ORTHOLOGY:   
K07553
KEGG Pathway:   
ko00600  ko01100 
Reactome:   
R-HSA-2022854
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9UBX8 
NCBI GeneID:   
9331
GlyMap GeneID:   
9331
DNA aRefSeq:   
NM_001330570.1 
Protein RefSeq:   
NP_001317499.1 
BRENDA:   
Kinetic info.
OMIM number:   
604017
GeneCards database:   
B4GALT6
Enzyme Specificity
Glycan Type:  
     GSL
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Glc(b1-?)Cer
Product:  
     Gal(b1-4)Glc(b1-?)Cer
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:    5.75e-04    (pmol/cell • hr)       KM:    1.50e+08    (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-148b-3p 3257-3264 -0.528 99.0 -0.265 94.0 con
hsa-miR-152-3p 3257-3264 -0.528 99.0 -0.265 94.0 con
hsa-miR-148a-3p 3257-3264 -0.528 99.0 -0.265 94.0 con
hsa-miR-5585-5p 1992-1999 -0.476 99.0 -0.455 99.0 noncon
hsa-miR-191-5p 317-323 -0.461 97.0 -0.461 98.0 noncon
hsa-miR-3174 459-466 -0.456 99.0 -0.456 99.0 noncon
hsa-miR-4746-3p 206-213 -0.43 97.0 -0.43 98.0 noncon
hsa-miR-921 460-467 -0.412 98.0 -0.412 99.0 noncon
hsa-miR-338-3p 33-40 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-509-3p 3898-3905 -0.402 97.0 0.0 0.0 noncon
hsa-miR-4715-5p 530-537 -0.393 98.0 -0.393 98.0 noncon
hsa-miR-106b-3p 1293-1299 -0.387 93.0 -0.37 95.0 noncon
hsa-miR-1288-3p 118-125 -0.379 97.0 -0.379 98.0 noncon
hsa-miR-4796-5p 430-437 -0.355 97.0 -0.355 98.0 noncon
hsa-miR-133a-3p.2 4153-4160 -0.348 94.0 0.0 0.0 noncon
hsa-miR-133b 4153-4160 -0.348 94.0 0.0 0.0 noncon
hsa-miR-5586-5p 35-41 -0.344 97.0 -0.344 98.0 noncon
hsa-miR-4318 1534-1541 -0.337 98.0 -0.323 98.0 noncon
hsa-miR-3177-5p 4090-4097 -0.324 91.0 0.0 0.0 noncon
hsa-miR-6887-3p 1147-1154 -0.324 93.0 -0.31 94.0 noncon
hsa-miR-3714 2165-2172 -0.323 99.0 -0.309 99.0 noncon
hsa-miR-205-5p 505-512 -0.323 98.0 -0.323 98.0 con
hsa-miR-3200-3p 18-25 -0.322 97.0 -0.322 98.0 noncon
hsa-miR-1911-5p 1952-1958 -0.321 93.0 -0.307 95.0 noncon
hsa-miR-3613-5p 3587-3594 -0.317 96.0 0.0 0.0 noncon
hsa-miR-376a-2-5p 2860-2867 -0.313 97.0 -0.166 93.0 noncon
hsa-miR-106a-3p 2428-2435 -0.313 98.0 -0.182 95.0 noncon
hsa-miR-5580-5p 113-120 -0.308 94.0 -0.308 96.0 noncon
hsa-miR-2114-5p 3764-3771 -0.304 97.0 0.0 0.0 noncon
hsa-miR-302f 1571-1578 -0.302 97.0 -0.289 98.0 noncon
hsa-miR-409-5p 3508-3515 -0.297 93.0 0.0 0.0 noncon
hsa-miR-335-5p 4205-4212 -0.297 98.0 0.0 0.0 noncon
hsa-miR-4738-3p 2134-2141 -0.294 98.0 -0.282 98.0 noncon
hsa-miR-5694 3858-3865 -0.287 98.0 0.0 0.0 noncon
hsa-miR-1323 2236-2243 -0.286 99.0 -0.274 99.0 noncon
hsa-miR-1304-5p 847-854 -0.285 95.0 -0.273 96.0 noncon
hsa-miR-6842-3p 2967-2974 -0.282 95.0 -0.15 86.0 noncon
hsa-miR-5590-5p 1787-1794 -0.282 96.0 -0.27 97.0 noncon
hsa-miR-3668 3247-3254 -0.281 95.0 -0.147 87.0 noncon
hsa-miR-377-3p 4275-4281 -0.278 95.0 0.0 0.0 noncon
hsa-miR-499b-5p 2180-2187 -0.276 96.0 -0.264 97.0 noncon
hsa-miR-1208 2338-2345 -0.274 98.0 -0.16 95.0 noncon
hsa-miR-758-5p 715-722 -0.272 98.0 -0.272 99.0 noncon
hsa-miR-1226-3p 3681-3687 -0.271 95.0 0.0 0.0 noncon
hsa-miR-20b-3p 2720-2727 -0.267 96.0 -0.143 91.0 noncon
hsa-miR-548o-3p 2236-2243 -0.267 99.0 -0.256 99.0 noncon
hsa-miR-4654 3288-3294 -0.264 95.0 -0.108 83.0 noncon
hsa-miR-6839-3p 1010-1017 -0.261 94.0 -0.25 95.0 noncon
hsa-miR-153-3p 4248-4255 -0.26 94.0 0.0 0.0 noncon
hsa-miR-513a-5p 2259-2266 -0.26 96.0 -0.157 93.0 noncon
hsa-miR-5694 995-1002 -0.258 98.0 -0.247 98.0 noncon
hsa-miR-1915-5p 17-23 -0.258 90.0 -0.258 93.0 noncon
hsa-miR-1179 305-311 -0.257 97.0 -0.257 98.0 noncon
hsa-miR-554 3766-3773 -0.256 93.0 0.0 0.0 noncon
hsa-miR-30a-5p 129-136 -0.255 93.0 -0.255 95.0 con
hsa-miR-30e-5p 129-136 -0.255 92.0 -0.255 94.0 con
hsa-miR-6514-5p 3996-4002 -0.255 96.0 0.0 0.0 noncon
hsa-miR-30d-5p 129-136 -0.255 93.0 -0.255 94.0 con
hsa-miR-4672 882-888 -0.254 97.0 -0.243 97.0 noncon
hsa-miR-548o-3p 558-565 -0.254 99.0 -0.254 99.0 noncon
hsa-miR-377-3p 497-504 -0.254 94.0 -0.254 96.0 con