GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
ST6GALNAC5



General Information
Gene Symbol:   
ST6GALNAC5
Protein name:   
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT29
E.C. No:   
2.4.99.7
Organs:   
Reaction (SNFG):   
+
→
+ CMP
Reaction (IUBMB):   
No specified reaction.
About

• ST6GALNAC-V/5 is responsible for the synthesis of GD1alpha from GM1b.
• Restricted expression in brain, and it is tightly regulated.

Related Pathway
KEGG ORTHOLOGY:   
K03375
KEGG Pathway:   
ko00604  ko01100 
Reactome:   
R-HSA-4085001
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9BVH7 
NCBI GeneID:   
81849
GlyMap GeneID:   
81849
DNA aRefSeq:   
NM_030965.2 
Protein RefSeq:   
NP_112227.1 
BRENDA:   
Kinetic info.
OMIM number:   
610134
GeneCards database:   
ST6GALNAC5
Enzyme Specificity
Glycan Type:  
     GSL
Compartment:  
     
Substrate:  
     NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-?)Cer
Product:  
     NeuAc(a2-3)Gal(b1-3)[NeuAc(a2-6)]GalNAc(b1-4)Gal(b1-4)Glc(b1-?)Cer
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3186-5p 130-137 -0.542 99.0 -0.542 99.0 noncon
hsa-miR-193b-3p 552-559 -0.529 99.0 -0.529 99.0 con
hsa-miR-193a-3p 552-559 -0.529 99.0 -0.529 99.0 con
hsa-miR-4804-5p 1811-1818 -0.502 97.0 -0.502 98.0 noncon
hsa-miR-6734-5p 3239-3246 -0.456 98.0 -0.128 80.0 noncon
hsa-miR-6508-3p 2783-2790 -0.444 98.0 -0.125 87.0 noncon
hsa-miR-7851-3p 25-32 -0.442 99.0 -0.442 99.0 noncon
hsa-miR-374c-3p 3280-3287 -0.409 98.0 -0.116 89.0 noncon
hsa-miR-1911-5p 1734-1741 -0.39 96.0 -0.39 97.0 noncon
hsa-miR-5088-5p 904-911 -0.389 98.0 -0.389 99.0 noncon
hsa-miR-138-5p 1565-1572 -0.388 96.0 -0.388 97.0 con
hsa-miR-760 1426-1433 -0.382 97.0 -0.382 97.0 noncon
hsa-miR-6808-5p 3363-3370 -0.372 99.0 -0.106 86.0 noncon
hsa-miR-6893-5p 3363-3370 -0.372 99.0 -0.106 86.0 noncon
hsa-miR-1262 2832-2839 -0.365 98.0 -0.105 83.0 noncon
hsa-miR-6878-3p 2222-2229 -0.364 97.0 -0.364 98.0 noncon
hsa-miR-3179 211-218 -0.364 97.0 -0.364 98.0 noncon
hsa-miR-2114-5p 1862-1869 -0.357 98.0 -0.357 99.0 noncon
hsa-miR-8085 2603-2610 -0.348 97.0 -0.1 75.0 noncon
hsa-miR-3605-3p 1698-1704 -0.347 93.0 -0.347 94.0 noncon
hsa-miR-2355-3p 796-803 -0.346 96.0 -0.346 97.0 noncon
hsa-miR-6736-5p 2832-2839 -0.344 98.0 -0.099 83.0 noncon
hsa-miR-6731-5p 2603-2610 -0.34 97.0 -0.098 75.0 noncon
hsa-miR-4421 76-83 -0.334 96.0 -0.334 97.0 noncon
hsa-miR-383-5p.2 3180-3187 -0.331 98.0 -0.096 87.0 noncon
hsa-miR-4701-3p 2832-2839 -0.325 97.0 -0.094 82.0 noncon
hsa-miR-4318 2644-2651 -0.321 98.0 -0.093 84.0 noncon
hsa-miR-185-5p 3169-3176 -0.32 97.0 -0.093 77.0 noncon
hsa-miR-4644 3169-3176 -0.32 97.0 -0.093 77.0 noncon
hsa-miR-4306 3169-3176 -0.32 97.0 -0.093 77.0 noncon
hsa-miR-6865-5p 1974-1980 -0.316 96.0 -0.316 97.0 noncon
hsa-miR-6815-5p 1974-1980 -0.316 96.0 -0.316 97.0 noncon
hsa-miR-940 3363-3370 -0.313 99.0 -0.091 85.0 noncon
hsa-miR-4714-5p 3031-3038 -0.31 97.0 -0.09 83.0 noncon
hsa-miR-4796-5p 346-353 -0.308 95.0 -0.308 97.0 noncon
hsa-miR-3691-3p 688-695 -0.301 97.0 -0.301 98.0 noncon
hsa-miR-3934-3p 2995-3002 -0.3 96.0 -0.087 77.0 noncon
hsa-miR-581 2695-2702 -0.3 96.0 -0.087 83.0 noncon
hsa-miR-24-3p 66-73 -0.298 97.0 -0.298 97.0 noncon
hsa-miR-219a-1-3p 1322-1329 -0.297 95.0 -0.297 97.0 noncon
hsa-miR-6876-5p 592-599 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-4476 592-599 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-15a-3p 628-635 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-4757-5p 2221-2228 -0.292 96.0 -0.292 97.0 noncon
hsa-miR-5699-3p 76-83 -0.292 95.0 -0.292 97.0 noncon
hsa-miR-152-5p 2514-2521 -0.291 95.0 -0.085 72.0 noncon
hsa-miR-6736-3p 233-240 -0.29 96.0 -0.29 97.0 noncon
hsa-miR-4666b 2073-2080 -0.285 96.0 -0.285 97.0 noncon
hsa-miR-6500-5p 1239-1246 -0.28 96.0 -0.28 97.0 noncon
hsa-miR-3174 1351-1358 -0.277 98.0 -0.277 98.0 noncon
hsa-miR-3620-3p 3427-3434 -0.274 96.0 -0.08 80.0 noncon
hsa-miR-6760-3p 3326-3332 -0.274 97.0 -0.08 85.0 noncon
hsa-miR-6864-5p 212-219 -0.272 95.0 -0.272 96.0 noncon
hsa-miR-4736 3362-3368 -0.272 97.0 -0.08 81.0 noncon
hsa-miR-3616-5p 2775-2782 -0.271 96.0 -0.079 82.0 noncon
hsa-miR-4786-3p 2243-2250 -0.271 95.0 -0.271 96.0 noncon
hsa-miR-1256 2655-2662 -0.267 94.0 -0.078 72.0 noncon
hsa-miR-596 448-454 -0.267 97.0 -0.267 98.0 noncon
hsa-miR-573 2775-2782 -0.266 96.0 -0.078 83.0 noncon
hsa-miR-6733-3p 53-60 -0.266 96.0 -0.266 97.0 noncon
hsa-miR-323b-5p 946-952 -0.265 91.0 -0.265 94.0 noncon
hsa-miR-8057 1427-1434 -0.265 98.0 -0.265 98.0 noncon
hsa-miR-4633-3p 1239-1246 -0.264 95.0 -0.264 96.0 noncon
hsa-miR-4255 2464-2471 -0.262 97.0 -0.262 98.0 noncon
hsa-miR-892b 1791-1798 -0.261 93.0 -0.261 95.0 noncon
hsa-miR-6874-5p 1240-1247 -0.259 93.0 -0.259 95.0 noncon
hsa-miR-107 2882-2889 -0.258 95.0 -0.076 78.0 noncon
hsa-miR-103a-3p 2882-2889 -0.258 95.0 -0.076 78.0 noncon
hsa-miR-6728-5p 963-970 -0.257 95.0 -0.257 96.0 noncon
hsa-miR-129-2-3p 2978-2985 -0.253 95.0 -0.075 81.0 con
hsa-miR-129-1-3p 2978-2985 -0.253 95.0 -0.075 80.0 con
hsa-miR-4795-5p 1647-1653 -0.252 94.0 -0.252 95.0 noncon