Gene Details: GMPPA
1 / 2
General Information
Gene Name: GMPPA (Mannose-1-phosphate guanylyltransferase regulatory subunit alpha)
Synonym:
Short Names:
Alternative Names: GDP-mannose pyrophosphorylase A;GTP-mannose-1-phosphate guanylyltransferase alpha;
Notes:
- Synthesizes GDP-mannose from mannose 1 phosphate and GTP.
- Knowledge of GMPPA and B is subsumed based on porcupine enzyme activity and the homology of porcupine and GMPPA and B structures.
- GDP-mannose is a critical reactant for sugar nucleotide synthesis and glycosylation, as it can be directly used in the synthesis of N-linked glycans and can be metabolized into other sugar nucleotide donors.
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
KEGG: 29926
Reactome :
R-HSA-446205
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| TCF25 | 0.573482 |
| SSU72 | 0.564397 |
| UBE2I | 0.560167 |
| YY1 | 0.546638 |
| SNRNP70 | 0.545841 |
| PHB2 | 0.534646 |
| SUMO1 | 0.534050 |
| NCOR1 | 0.532651 |
| XRCC5 | 0.530964 |
| ATF4 | 0.530562 |
Licensing: CC BY 4.0. You are fee to copy, redistribute, remix, transform and build upon all material, except for textbook figures from the Essentials.