Gene Details: ALG1
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General Information
Gene Name: ALG1 (Chitobiosyldiphosphodolichol beta-mannosyltransferase)
Synonym: HMAT1
Short Names:
Alternative Names: Asparagine-linked glycosylation protein 1 homolog;Beta-1,4-mannosyltransferase;GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase;GDP-mannose-dolichol diphosphochitobiose mannosyltransferase;Mannosyltransferase-1;
Notes:
- These enzymes (Alg1, Alg2, Alg11) sequentially add 5-mannose from GDP-man to generate Man5Glc2-PP-Dol.
- Alg1 is a β1-4Mannosyltransferase.
- Alg2 adds both α(1-3) and α(1-6) Mannose to Man1GlcNAc2-PP-Dol.
- Alg11 adds additional α(1-2)Man to the 3-arm of the N-glycan precursor
- Alg1, Alg2, and Alg11 mannosyltransferases are ER membrane proteins with catalytic domains that face the cytosol and that use GDP-man as the sugar donor for mannosylation.
- Deficiencies in Alg1, Alg2, and Alg11 result in CDG-Ik, CDG-Ii and CDG-Ip, respectively.
- Intermediate glycans built on dolichol phosphate containing 7 monosaccharides are flipped into the ER lumen. This is further built with 4 additional Man and 3 Glc.
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
EC # (IUBMB):
2.4.1.142
Brenda:
2.4.1.142
KEGG: 56052
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| SSU72 | 0.321564 |
| TCF25 | 0.318631 |
| UBE2I | 0.317178 |
| SNRNP70 | 0.310942 |
| SUMO1 | 0.307937 |
| NCOR1 | 0.306825 |
| NONO | 0.304548 |
| PHB2 | 0.303410 |
| YY1 | 0.301645 |
| BRD4 | 0.299824 |
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