Gene Details: ALG11
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General Information
Gene Name: ALG11 (GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase)
Synonym: GT8
Short Names:
Alternative Names: Asparagine-linked glycosylation protein 11 homolog;Glycolipid 2-alpha-mannosyltransferase;
Notes:
- These enzymes (Alg1, Alg2, Alg11) sequentially add 5-mannose from GDP-man to generate Man5Glc2-PP-Dol.
- Alg1 is a β1-4Mannosyltransferase.
- Alg2 adds both α(1-3) and α(1-6) Mannose to Man1GlcNAc2-PP-Dol.
- Alg11 adds additional α(1-2)Man to the 3-arm of the N-glycan precursor
- Alg1, Alg2, and Alg11 mannosyltransferases are ER membrane proteins with catalytic domains that face the cytosol and that use GDP-man as the sugar donor for mannosylation.
- Deficiencies in Alg1, Alg2, and Alg11 result in CDG-Ik, CDG-Ii and CDG-Ip, respectively.
- Intermediate glycans built on dolichol phosphate containing 7 monosaccharides are flipped into the ER lumen. This is further built with 4 additional Man and 3 Glc.
Description from Dr.Glyco-GPT:
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Catalytic Activity
Reaction and Disease Links
EC # (IUBMB):
2.4.1.131
Brenda:
2.4.1.131
KEGG: 440138
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| UBE2I | 0.218396 |
| TCF25 | 0.217820 |
| SNRNP70 | 0.213943 |
| SSU72 | 0.212861 |
| NCOR1 | 0.212023 |
| YY1 | 0.210889 |
| SRSF4 | 0.208816 |
| BCLAF1 | 0.208484 |
| BRD4 | 0.206227 |
| NONO | 0.205767 |
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