Gene Details: ALG12
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General Information
Gene Name: ALG12 (Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase)
Synonym:
Short Names:
Alternative Names: Asparagine-linked glycosylation protein 12 homolog;Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase;Mannosyltransferase ALG12 homolog;Membrane protein SB87;
Notes:
- Extension of Man5GlcNAc2-P-P-Dol in the ER lumen involves the addition of four Man (by ALG3 [α(1,3)ManT], ALG9 [α(1,2)ManT], ALG12 [α(1,6)ManT] followed by ALG9 [α(1,2)ManT] again) and three Glc residues (by ALG6 [α(1,3)GlcT], ALG8 [α(1,3)GlcT] and ALG10 [α(1,2)GlcT]).
- In all instances the transfer uses either Dol-P-Man or Dol-P-Glc as donor.
- Dol-P-Man is formed from GDP-Man using enzymes DPM1,2,3.
- Dol-P-Glc is formed from UDP-Glc using ALG5.
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
EC # (IUBMB):
2.4.1.260
Brenda:
2.4.1.260
KEGG: 79087
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| TCF25 | 0.339529 |
| UBE2I | 0.338884 |
| SSU72 | 0.337863 |
| SNRNP70 | 0.332401 |
| YY1 | 0.328039 |
| NCOR1 | 0.324836 |
| SUMO1 | 0.321741 |
| SRSF4 | 0.321116 |
| BRD4 | 0.320652 |
| NONO | 0.320117 |
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