Gene Details: ALG2
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General Information
Gene Name: ALG2 (Programmed cell death protein 6)
Synonym: ALG2
Short Names:
Alternative Names: Apoptosis-linked gene 2 protein homolog;
Notes:
- These enzymes (Alg1, Alg2, Alg11) sequentially add 5-mannose from GDP-man to generate Man5Glc2-PP-Dol.
- Alg1 is a β1-4Mannosyltransferase.
- Alg2 adds both α(1-3) and α(1-6) Mannose to Man1GlcNAc2-PP-Dol.
- Alg11 adds additional α(1-2)Man to the 3-arm of the N-glycan precursor.
- Alg1, Alg2, and Alg11 mannosyltransferases are ER membrane proteins with catalytic domains that face the cytosol and that use GDP-man as the sugar donor for mannosylation.
- Deficiencies in Alg1, Alg2, and Alg11 result in CDG-Ik, CDG-Ii and CDG-Ip, respectively.
- Intermediate glycans built on dolichol phosphate containing 7 monosaccharides are flipped into the ER lumen. This is further built with 4 additional Man and 3 Glc.
Description from Dr.Glyco-GPT:
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Catalytic Activity
Reaction and Disease Links
OMIM:
601057
KEGG: 10016
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| TCF25 | 0.827236 |
| UBE2I | 0.818840 |
| SSU72 | 0.808313 |
| XRCC5 | 0.795350 |
| YY1 | 0.792401 |
| RBM39 | 0.786792 |
| SON | 0.784311 |
| HNRNPK | 0.778579 |
| SNRNP70 | 0.777202 |
| RBM25 | 0.773763 |
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