Gene Details: ALG3
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General Information
Gene Name: ALG3 (Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase)
Synonym: NOT
Short Names:
Alternative Names: Asparagine-linked glycosylation protein 3 homolog;Dol-P-Man-dependent alpha(1-3)-mannosyltransferase;Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase;Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase;Not56-like protein;
Notes:
- Extension of Man5GlcNAc2-P-P-Dol in the ER lumen involves the addition of four Man (by ALG3 [α(1,3)ManT], ALG9 [α(1,2)ManT], ALG12 [α(1,6)ManT] followed by ALG9 [α(1,2)ManT] again) and three Glc residues (by ALG6 [α(1,3)GlcT], ALG8 [α(1,3)GlcT] and ALG10 [α(1,2)GlcT]).
- In all instances the transfer uses either Dol-P-Man or Dol-P-Glc as donor.
- Dol-P-Man is formed from GDP-Man using enzymes DPM1,2,3.
- Dol-P-Glc is formed from UDP-Glc using ALG5.
- Alg 3 is the first enzyme that acts on the lumen-oriented LLO. It adds α1,3-linked mannose to the α1,6 mannose arm. The enzyme uses dolichylphosphomannose (Dol-P-Man) as a donor and Man5GlcNAc2-PP-Dol as an acceptor substrate.
- Mutations in Alg 3 results in CDG-Id.
Description from Dr.Glyco-GPT:
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Catalytic Activity
Reaction and Disease Links
EC # (IUBMB):
2.4.1.258
Brenda:
2.4.1.258
KEGG: 10195
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| UBE2I | 0.811981 |
| TCF25 | 0.806508 |
| SSU72 | 0.804811 |
| XRCC5 | 0.776163 |
| YY1 | 0.771830 |
| PHB2 | 0.765812 |
| SNRNP70 | 0.763972 |
| SUMO1 | 0.759696 |
| RBM39 | 0.759449 |
| SON | 0.758523 |
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