Gene Details: ALG8
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General Information
Gene Name: ALG8 (Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase)
Synonym:
Short Names:
Alternative Names: Asparagine-linked glycosylation protein 8 homolog;Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase;Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase;
Notes:
- Dol-P-Glc is formed from UDP-Glc using ALG5.
- Three Glc residues are then transferred from Dol-P-Glc to the LLO using ALG6 [α(1,3)GlcT], ALG8 [α(1,3)GlcT] and ALG10 [α(1,2)GlcT].
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
EC # (IUBMB):
2.4.1.265
Brenda:
2.4.1.265
KEGG: 79053
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| UBE2I | 0.519950 |
| TCF25 | 0.514625 |
| SSU72 | 0.509617 |
| NCOR1 | 0.498845 |
| SNRNP70 | 0.498591 |
| YY1 | 0.498310 |
| ZNF207 | 0.487124 |
| XRCC5 | 0.486534 |
| SRSF4 | 0.486372 |
| SUMO1 | 0.485270 |
Licensing: CC BY 4.0. You are fee to copy, redistribute, remix, transform and build upon all material, except for textbook figures from the Essentials.