Gene Details: DAD1
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General Information
Gene Name: DAD1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1)
Synonym:
Short Names: Oligosaccharyl transferase subunit DAD1;
Alternative Names: Defender against cell death 1;
Notes:
- A multi-membrane protein ER membrane associated protein complex that mediates the en-bloc transfer of 14 sugar LLO to N-X-S/T motif in nascent polypeptide.
- STT3 is the catalytic core of this complex.
- STT3 forms a complex with the accessory membrane proteins DDOST/OST48, RPN1/ribophorin I, RPN2/ribophorin II, DAD1, Ost4, TUSC3/N33 and MGAT1/IAP in mammals for maximal ativity.
- There are two STT3 genes: STT3A and STT3B. Human Stt3A and Stt3B have redundant functions in the co-translational N-glycosylation. Stt3B also mediates the post-translational N-glycosylation after some time, rather than just at the time when the protein enters the ER from the ribosome.
- Reaction catalyzed: Glc[0-3]Man[0-9]GlcNAc2β1-PP-Dol + Asn-Xaa-Ser/Thr -> Dol-PP + Glc[0-3]Man[0-9]GlcNAc2β1-Asn-Xaa-Ser/Thr.
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
Brenda:
2.4.99.18
OMIM:
600243
KEGG: 1603
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| HNRNPK | 2.844314 |
| SUMO2 | 2.841553 |
| SON | 2.806482 |
| RBM39 | 2.764394 |
| PCBP2 | 2.688841 |
| PCBP1 | 2.682747 |
| SRSF3 | 2.675017 |
| HMGB1 | 2.627277 |
| XRCC5 | 2.580345 |
| FUS | 2.567417 |
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