Gene Details: DPAGT1
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General Information
Gene Name: DPAGT1 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase)
Synonym: DPAGT2
Short Names:
Alternative Names: GlcNAc-1-P transferase;N-acetylglucosamine-1-phosphate transferase;
Notes:
- ALG7/DPAGT1 initiates the synthesis of 14 sugar Glc3Man9GlcNAc2 on dolichol pyrophosphate. This is a lipid linked oligosaccaride (LLO) where 7 monosaccharides are added in the cytoplasmic side and 7 in the ER lumen.
- ALG7 adds GlcNAc to dolichol phosphate (P-Dol) to generate GlcNAc-PP-Dol.
- Tunicamycin acts as a tight-binding competitive inhibitor of DPAGT1, presumably because it structurally resembles the donor nucleotide sugar.
- Mice lacking DPAGT1 are embyonic lethal in early days following implantation.
- CDG type I are a class of Congenital Disorders of Glycosylation that reduces site occupany of N-glycans. Enzymes causing CDG-I are commonly associated with deficiencies in LLO biosynthesis.
- ALG7/DPAGT1 Mutations in human results in CDG-Ij. It also causes Limb-Girdle congential myasthenic syndrome.
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
EC # (IUBMB):
2.7.8.15
Brenda:
2.7.8.15
KEGG: 1798
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| SSU72 | 0.473849 |
| TCF25 | 0.469465 |
| UBE2I | 0.468981 |
| SNRNP70 | 0.460092 |
| NCOR1 | 0.454404 |
| YY1 | 0.448735 |
| SUMO1 | 0.448064 |
| SRSF4 | 0.444245 |
| PHB2 | 0.443683 |
| BRD4 | 0.442661 |
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