Gene Details: RPN1
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General Information
Gene Name: RPN1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1)
Synonym:
Short Names:
Alternative Names: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit;Ribophorin I;Ribophorin-1;
Notes:
- A multi-membrane protein ER membrane associated protein complex that mediates the en-bloc transfer of 14 sugar LLO to N-X-S/T motif in nascent polypeptide.
- STT3 is the catalytic core of this complex.
- Stt3 forms a complex with the accessory membrane proteins DDOST/OST48, RPN1/ribophorin I, RPN2/ribophorin II, DAD1, Ost4, TUSC3/N33 and MGAT1/IAP in mammals for maximal ativity.
- There are two STT3 genes: STT3A and STT3B. Human Stt3A and Stt3B have redundant functions in the co-translational N-glycosylation. Stt3B also mediates the post-translational N-glycosylation after some time, rather than just at the time when the protein enters the ER from the ribosome.
- Reaction catalyzed: Glc[0-3]Man[0-9]GlcNAc2β1-PP-Dol + Asn-Xaa-Ser/Thr -> Dol-PP + Glc[0-3]Man[0-9]GlcNAc2β1-Asn-Xaa-Ser/Thr.
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
Brenda:
2.4.99.18
OMIM:
180470
KEGG: 6184
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| SON | 1.828812 |
| RBM39 | 1.825088 |
| HNRNPK | 1.818054 |
| PCBP1 | 1.802422 |
| TCF25 | 1.764910 |
| SRSF3 | 1.746769 |
| PCBP2 | 1.742244 |
| XRCC5 | 1.739791 |
| SUMO2 | 1.723237 |
| SFPQ | 1.715769 |
Licensing: CC BY 4.0. You are fee to copy, redistribute, remix, transform and build upon all material, except for textbook figures from the Essentials.