Gene Details: STT3A
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General Information
Gene Name: STT3A (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A)
Synonym: ITM1
Short Names: Oligosaccharyl transferase subunit STT3A;STT3-A;
Alternative Names: B5;Integral membrane protein 1;Transmembrane protein TMC;
Notes:
- A multi-membrane protein ER membrane associated protein complex that mediates the en-bloc transfer of 14 sugar LLO to N-X-S/T motif in nascent polypeptide.
- STT3 is the catalytic core of this complex.
- Stt3 forms a complex with the accessory membrane proteins DDOST/OST48, RPN1/ribophorin I, RPN2/ribophorin II, DAD1, Ost4, TUSC3/N33 and MGAT1/IAP in mammals for maximal ativity.
- There are two STT3 genes: STT3A and STT3B. Human Stt3A and Stt3B have redundant functions in the co-translational N-glycosylation. Stt3B also mediates the post-translational N-glycosylation after some time, rather than just at the time when the protein enters the ER from the ribosome.
- Reaction catalyzed: Glc[0-3]Man[0-9]GlcNAc2β1-PP-Dol + Asn-Xaa-Ser/Thr -> Dol-PP + Glc[0-3]Man[0-9]GlcNAc2β1-Asn-Xaa-Ser/Thr.
Description from Dr.Glyco-GPT:
Warning: LLMs can generate factually incorrect information, as they simply predict the next word based on training data. Always verify LLM output by cross-checking with reliable sources!
Catalytic Activity
Reaction and Disease Links
EC # (IUBMB):
2.4.99.18
Brenda:
2.4.99.18
KEGG: 3703
Transcript levels (Cell lines and Single cell data) URL
CRISPR-knockout
CRISPR-activation
CRISPR-inactivation
Transcription factor-gene relationship (details at glycoTF page)
Top 10 TFs
| TF | Score |
|---|---|
| TCF25 | 0.824635 |
| UBE2I | 0.800314 |
| SSU72 | 0.791577 |
| XRCC5 | 0.789197 |
| RBM39 | 0.787920 |
| YY1 | 0.785708 |
| SON | 0.785176 |
| SNRNP70 | 0.780601 |
| RBM25 | 0.772196 |
| HNRNPK | 0.770627 |
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